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首页> 美国卫生研究院文献>Environmental Health Perspectives >Risk of Incident Diabetes in Relation to Long-term Exposure to Fine Particulate Matter in Ontario Canada
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Risk of Incident Diabetes in Relation to Long-term Exposure to Fine Particulate Matter in Ontario Canada

机译：与加拿大安大略省长期长期接触细颗粒物有关的发生糖尿病的风险

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Background: Laboratory studies suggest that fine particulate matter (≤ 2.5 µm in diameter; PM2.5) can activate pathophysiological responses that may induce insulin resistance and type 2 diabetes. However, epidemiological evidence relating PM2.5 and diabetes is sparse, particularly for incident diabetes.Objectives: We conducted a population-based cohort study to determine whether long-term exposure to ambient PM2.5 is associated with incident diabetes.Methods: We assembled a cohort of 62,012 nondiabetic adults who lived in Ontario, Canada, and completed one of five population-based health surveys between 1996 and 2005. Follow-up extended until 31 December 2010. Incident diabetes diagnosed between 1996 and 2010 was ascertained using the Ontario Diabetes Database, a validated registry of persons diagnosed with diabetes (sensitivity = 86%, specificity = 97%). Six-year average concentrations of PM2.5 at the postal codes of baseline residences were derived from satellite observations. We used Cox proportional hazards models to estimate the associations, adjusting for various individual-level risk factors and contextual covariates such as smoking, body mass index, physical activity, and neighborhood-level household income. We also conducted multiple sensitivity analyses. In addition, we examined effect modification for selected comorbidities and sociodemographic characteristics.Results: There were 6,310 incident cases of diabetes over 484,644 total person-years of follow-up. The adjusted hazard ratio for a 10-µg/m3 increase in PM2.5 was 1.11 (95% CI: 1.02, 1.21). Estimated associations were comparable among all sensitivity analyses. We did not find strong evidence of effect modification by comorbidities or sociodemographic covariates.Conclusions: This study suggests that long-term exposure to PM2.5 may contribute to the development of diabetes.
机译：背景：实验室研究表明，细颗粒物（直径≤2.5 µm； PM2.5）可以激活可能引起胰岛素抵抗和2型糖尿病的病理生理反应。然而，与PM2.5和糖尿病相关的流行病学证据很少，尤其是对于突发性糖尿病。目的：我们进行了一项基于人群的队列研究，以确定长期暴露于环境PM2.5是否与突发性糖尿病有关。一组62,012名非糖尿病成年人，他们生活在加拿大安大略省，并在1996年至2005年之间完成了五项基于人口的健康调查之一。随访期延长至2010年12月31日。1996年至2010年之间诊断为糖尿病的事件是使用安大略糖尿病确定的数据库，一个经过验证的诊断为糖尿病患者的注册表（敏感性= 86％，特异性= 97％）。基线观测的邮政编码的六年平均PM2.5浓度来自卫星观测。我们使用Cox比例风险模型估算了相关性，并针对各种个人风险因素和上下文协变量进行了调整，例如吸烟，体重指数，体育锻炼和邻里家庭收入。我们还进行了多种敏感性分析。此外，我们还研究了针对某些合并症和社会人口统计学特征的效果改善。结果：发生了6,310例糖尿病，超过484,644人/年的随访。 PM2.5浓度每增加10 µg / m 3 的调整后危险比为1.11（95％CI：1.02，1.21）。在所有敏感性分析中，估计的关联性均具有可比性。我们没有发现合并症或社会人口统计学协变量改善疗效的有力证据。结论：这项研究表明，长期暴露于PM2.5可能有助于糖尿病的发展。

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