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首页> 美国卫生研究院文献>Environmental Health Perspectives >Polymorphisms in Genes Encoding Potential Mercury Transporters and Urine Mercury Concentrations in Populations Exposed to Mercury Vapor from Gold Mining
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Polymorphisms in Genes Encoding Potential Mercury Transporters and Urine Mercury Concentrations in Populations Exposed to Mercury Vapor from Gold Mining

机译：金矿中汞蒸气暴露人群中潜在汞转运蛋白和尿中汞浓度编码基因的多态性

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Background: Elemental mercury (Hg0) is widely used in small-scale gold mining. Persons working or living in mining areas have high urinary concentrations of Hg (U-Hg). Differences in genes encoding potential Hg-transporters may affect uptake and elimination of Hg.Objective: We aimed to identify single nucleotide polymorphisms (SNPs) in Hg-transporter genes that modify U-Hg.Methods: Men and women (1,017) from Indonesia, the Philippines, Tanzania, and Zimbabwe were classified either as controls (no Hg exposure from gold mining) or as having low (living in a gold-mining area) or high exposure (working as gold miners). U-Hg was analyzed by cold-vapor atomic absorption spectrometry. Eighteen SNPs in eight Hg-transporter genes were analyzed.Results: U-Hg concentrations were higher among ABCC2/MRP2 rs1885301 A–allele carriers than among GG homozygotes in all populations, though differences were not statistically significant in most cases. MRP2 SNPs showed particularly strong associations with U-Hg in the subgroup with highest exposure (miners in Zimbabwe), whereas rs1885301 A–allele carriers had higher U-Hg than GG homozygotes [geometric mean (GM): 36.4 µg/g creatinine vs. 21.9; p = 0.027], rs2273697 GG homozygotes had higher U-Hg than A–allele carriers (GM: 37.4 vs. 16.7; p = 0.001), and rs717620 A–allele carriers had higher U-Hg than GG homozygotes (GM: 83 vs. 28; p = 0.084). The SLC7A5/LAT1 rs33916661 GG genotype was associated with higher U-Hg in all populations (statistically significant for all Tanzanians combined). SNPs in SLC22A6/OAT1 (rs4149170) and SLC22A8/OAT3 (rs4149182) were associated with U-Hg mainly in the Tanzanian study groups.Conclusions: SNPs in putative Hg-transporter genes may influence U-Hg concentrations.
机译：背景：元素汞（Hg 0 ）被广泛用于小型金矿开采。在矿区工作或生活的人尿中的汞含量较高（U-Hg）。目的：我们旨在鉴定修饰U-Hg的Hg转运蛋白基因中的单核苷酸多态性（SNP）。方法：来自印度尼西亚的男性和女性（1,017），菲律宾，坦桑尼亚和津巴布韦被分类为对照（没有来自金矿开采的汞暴露），或者被归类为低（生活在金矿地区）或高暴露（作为金矿开采者）。通过冷蒸气原子吸收光谱法分析了U-Hg。结果：在所有人群中，ABCC2 / MRP2 rs1885301 A等位基因携带者中的U-Hg浓度高于GG纯合子中的U-Hg浓度，尽管在大多数情况下差异均无统计学意义。 MRP2 SNPs在暴露度最高的亚组（津巴布韦的矿工）中表现出与U-Hg的特别强的联系，而rs1885301 A等位基因携带者的U-Hg高于GG纯合子[几何平均值（GM）：36.4 µg / g肌酐与GS。 21.9； p = 0.027]，rs2273697 GG纯合子的U-Hg高于A等位基因携带者（GM：37.4比16.7； p = 0.001），而rs717620 A等位基因携带者的U-Hg比GG纯合子更高（GM：83 vs 28； p ＝ 0.084）。 SLC7A5 / LAT1 rs33916661 GG基因型与所有人群中较高的U-Hg相关（对所有坦桑尼亚人而言，统计意义均显着）。 SLC22A6 / OAT1（rs4149170）和SLC22A8 / OAT3（rs4149182）中的SNPs与U-Hg相关，主要在坦桑尼亚研究组中。结论：假定的Hg-转运蛋白基因中的SNPs可能影响U-Hg浓度。

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