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Hospital-Associated Multicenter Outbreak of Emerging FungusCandida auris Colombia 2016

机译:医院相关的新兴真菌多中心暴发哥伦比亚念珠菌(Candida auris)哥伦比亚2016年

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摘要

Candida auris is an emerging multidrug-resistant fungus that causes hospital-associated outbreaks of invasive infections with high death rates. During 2015–2016, health authorities in Colombia detected an outbreak of C. auris. We conducted an investigation to characterize the epidemiology, transmission mechanisms, and reservoirs of this organism. We investigated 4 hospitals with confirmed cases of C. auris candidemia in 3 cities in Colombia. We abstracted medical records and collected swabs from contemporaneously hospitalized patients to assess for skin colonization. We identified 40 cases; median patient age was 23 years (IQR 4 months–56 years). Twelve (30%) patients were <1 year of age, and 24 (60%) were male. The 30-day mortality was 43%. Cases clustered in time and location; axilla and groin were the most commonly colonized sites. Temporal and spatial clustering of cases and skin colonization suggest person-to-person transmission of C. auris. These cases highlight the importance of adherence to infection control recommendations.
机译:假丝酵母是一种新兴的耐多药真菌,可引起医院相关的高死亡率的侵袭性感染暴发。在2015–2016年期间,哥伦比亚卫生部门检测到暴发了金黄色葡萄球菌。我们进行了一项调查,以表征这种生物的流行病学,传播机制和储库。我们调查了哥伦比亚3个城市的4所确诊为念珠菌念珠菌病的医院。我们提取了病历并从同时住院的患者中收集了拭子以评估皮肤定植。我们确定了40例;患者中位年龄为23岁(IQR 4个月至56岁)。 12岁(30%)患者<1岁,男性24(60%)。 30天死亡率为43%。案件按时间和地点分类;腋窝和腹股沟是最常见的定居地点。病例的时间和空间聚集以及皮肤定植表明金黄色葡萄球菌的人际传播。这些案例凸显了遵守感染控制建议的重要性。

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