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首页> 美国卫生研究院文献>ecancermedicalscience >Penile melanoma: a 20-Year analysis of six patients at the National Cancer Institute of Peru Lima
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Penile melanoma: a 20-Year analysis of six patients at the National Cancer Institute of Peru Lima

机译：阴茎黑色素瘤：秘鲁国家癌症研究所对20名患者的20年分析利马

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Melanoma of the urogenital tract is extremely rare, accounting for less than 0.1% of melanoma cases. The global literature currently describes only 220 cases of penile melanoma, most commonly located on the glans penis.ResultsPenile melanoma accounts for 0.7% of penile cancers and 0.18% of melanoma cases. The average patient age for the six cases we reviewed was 44.5 years. Three of these cases (50%) involved ulceration, one case (16.7%) involved lymphovascular invasion, and three cases (50%) involved mitosis ≥ 1 mm2 (0.38–4.7 mm). The average depth of invasion (Breslow) in the five cases that reported this measure was 2.1 mm (0.38–4.7 mm). Applying the American Joint Committee on Cancer tumour, node, metastases (AJCC TNM) staging system, one case was Tx (16.7%), two cases were T1 (33.3%), one case was T2 (16.7%), one case was T3 (16.7%), and one case was T4 (16.7%). Five cases (83.3%) involved wide local resection, and only one case involved partial penile amputation. Four cases (66.7%) involved primary bilateral inguinocrural lymphadenectomy, and only one of those four cases involved lymphatic metastatic disease. One case (16.7%) involved lymphatic recurrence at 12 months in a patient who survived 38 months. One case (16.7%) involved local recurrence at 13 months in a patient who has survived 53 months. Eighty per cent of these patients remain alive, with no evidence of disease after an average follow-up of 96.7 months.
机译：泌尿生殖道黑素瘤极为罕见，占黑素瘤病例的不到0.1％。目前，全球文献仅描述了220例阴茎黑色素瘤，最常见于阴茎龟头。结果阴茎黑色素瘤占阴茎癌的0.7％，占黑色素瘤病例的0.18％。我们审查的六例患者的平均患者年龄为44.5岁。其中三例（50％）涉及溃疡，一例（16.7％）涉及淋巴管浸润，三例（50％）涉及≥1 mm 2 （0.38–4.7 mm）的有丝分裂。在报告该措施的五例病例中，平均浸润深度（Breslow）为2.1毫米（0.38-4.7毫米）。应用美国癌症肿瘤，淋巴结转移联合委员会（AJCC TNM）分期系统，一例为Tx（16.7％），二例为T1（33.3％），一例为T2（16.7％），一例为T3 （16.7％），其中一例为T4（16.7％）。 5例（83.3％）涉及广泛的局部切除，只有1例涉及部分阴茎截肢。四例（66.7％）涉及双侧原发性腹股沟淋巴结清扫术，而这四例中只有一例涉及淋巴结转移性疾病。 1例（16.7％）患者生存38个月，在12个月时发生淋巴结复发。 1例（16.7％）患者中生存53个月的患者在13个月时局部复发。在平均随访96.7个月后，这些患者中有80％仍然活着，没有疾病的迹象。

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