首页> 美国卫生研究院文献>EBioMedicine >Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis

【2h】

Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis

机译：测量人原代肺细胞功能反应作为囊性纤维化个性化治疗的基础

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundThe best investigational drug to treat cystic fibrosis (CF) patients with the most common CF-causing mutation (F508del) is VX-809 (lumacaftor) which recently succeeded in Phase III clinical trial in combination with ivacaftor. This corrector rescues F508del-CFTR from its abnormal intracellular localization to the cell surface, a traffic defect shared by all Class II CFTR mutants. Our goal here is to test the efficacy of lumacaftor in other Class II mutants in primary human bronchial epithelial (HBE) cells derived from CF patients.

机译：背景技术治疗具有最常见的CF致突变（F508del）的囊性纤维化（CF）患者的最佳研究药物是VX-809（lumacaftor），该药物最近与ivacaftor结合在III期临床试验中获得了成功。该校正子将F508del-CFTR从其异常的细胞内定位拯救到细胞表面，这是所有II类CFTR突变体共有的交通缺陷。我们的目标是在源自CF患者的原代人支气管上皮（HBE）细胞中测试lumacaftor在其他II类突变体中的功效。

著录项

期刊名称 EBioMedicine
作者
Nikhil T. Awatade; Inna Uliyakina; Carlos M. Farinha; Luka A. Clarke; Karina Mendes; Amparo Solé; Juan Pastor; Maria Margarida Ramos; Margarida D. Amaral;
展开▼
作者单位

展开▼
年(卷),期 2015(2),2
年度 2015
页码 147–153
总页数 7
原文格式 PDF
正文语种
中图分类
关键词
Innovative treatments Mutation-specific therapies Personalized medicine Rare diseases;

机译：创新疗法;突变疗法;个性化药物;罕见病;

相似文献

外文文献
中文文献
专利

1. Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis [J] . Nikhil T. Awatade, Inna Uliyakina, Carlos M. Farinha, EBioMedicine . 2015,第2期

机译：测量人原代肺细胞功能反应作为囊性纤维化个性化治疗的基础
2. Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis [J] . Nikhil T. Awatade, Inna Uliyakina, Carlos M. Farinha, EBioMedicine . 2015,第2期

机译：测量人原代肺细胞功能反应作为囊性纤维化个性化治疗的基础
3. IN VITRO 3D CULTURE LUNG MODELS FROM EXPANDED PRIMARY CYSTIC FIBROSIS HUMAN AIRWAY CELLS [J] . Rayner R. E., Wellmerling J., Osman W., Pediatric Pulmonology . 2019,第Suppla2期

机译：来自膨胀初级囊性纤维化人气通道细胞的体外3D培养肺模型
4. OMICS approaches to reveal Burkholderia cenocepacia adaptive strategies to long-term residence in the lungs of cystic fibrosis patients under antibiotic therapy [C] . Madeira Andreia, Mira Nuno P, Santos Pedro M, 1st Portuguese Meeting in Bioengineering . 2011

机译：OMICS方法揭示在抗生素治疗下囊性纤维化患者长期驻留在肺泡中的伯克霍尔德菌种的适应策略
5. Polymicrobial Infections in Cystic Fibrosis Lungs: The Need for Personalized Treatment. [D] . Lim, Yan Wei. 2015

机译：囊性纤维化肺中的微生物感染：需要个性化治疗。
6. Human Primary Epithelial Cell Models: Promising Tools in the Era of Cystic Fibrosis Personalized Medicine [O] . Nikhil T. Awatade, Sharon L. Wong, Chris K. Hewson, 2018

机译：人原代上皮细胞模型：囊性纤维化时代的有前途的工具个性化医学
7. Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis [O] . Nikhil T. Awatade, Inna Uliyakina, Carlos M. Farinha, 2015

机译：人类原代肺细胞功能反应的测量，作为囊性纤维化个体化治疗的基础

Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis

摘要

著录项

相似文献

相关主题

期刊订阅