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Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimers Disease and Mild Cognitive Impairment: A Multicenter Randomized Double-blind Placebo-controlled Trial

机译：轻度阿尔茨海默氏病和轻度认知障碍患者口服血浆生成素的疗效和血中血浆生成素变化：多中心随机双盲安慰剂对照试验

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BackgroundPlasmalogens (Pls) reportedly decreased in postmortem brain and in the blood of patients with Alzheimer's disease (AD). Recently we showed that intraperitoneal administration of Pls improved cognitive function in experimental animals. In the present trial, we tested the efficacy of oral administration of scallop-derived purified Pls with respect to cognitive function and blood Pls changes in patients with mild AD and mild cognitive impairment (MCI).

机译：背景据报道，阿尔茨海默氏病（AD）患者的死后大脑和血液中的血浆致黄素（Pls）减少。最近，我们显示腹膜内注射Pls可改善实验动物的认知功能。在本试验中，我们测试了轻度AD和轻度认知障碍（MCI）患者口服给药扇贝衍生的纯化Pls对认知功能和血液Pls变化的功效。

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期刊名称 EBioMedicine
作者
Takehiko Fujino; Tatsuo Yamada; Takashi Asada; Yoshio Tsuboi; Chikako Wakana; Shiro Mawatari; Suminori Kono;
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作者单位

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年(卷),期 2017(17),-1
年度 2017
页码 199–205
总页数 7
原文格式 PDF
正文语种
中图分类
关键词
Plasmalogen Scallop Alzheimers disease Mild cognitive impairment Cognitive function;

机译：疟原虫;扇贝;阿尔茨海默氏病;轻度认知障碍;认知功能;

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1. Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimer's Disease and Mild Cognitive Impairment: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial [J] . Takehiko Fujino, Tatsuo Yamada, Takashi Asada, EBioMedicine . 2017,第4期

机译：轻度阿尔茨海默氏病和轻度认知障碍患者口服血浆生成素的疗效和血液中血浆血浆生成素的变化：多中心，随机，双盲，安慰剂对照试验
2. Effectiveness of blood plasmalogen in differentiation among mild cognitive impairment, Mild Alzheimer's disease and normal elderly [J] . S. Ouma, Y. Tsuboi, S. Mawatari, Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology . 2017,第期

机译：轻度认知障碍分化血浆血浆的有效性，轻度阿尔茨海默病和正常老年人
3. Efficacy and safety of Ginkgo biloba extract EGb 761? in mild cognitive impairment with neuropsychiatric symptoms: A randomized, placebo-controlled, double-blind, multicenter trial [J] . GavrilovaS.I., PreussU.W., WongJ.W.M., International journal of geriatric psychiatry . 2014,第10期

机译：银杏叶提取物EGB 761的功效和安全性？神经精神症状的轻度认知障碍患者：一项随机，安慰剂对照，双盲，多中心试验
4. A Randomized, Placebo-Controlled Study of the Efficacy of Cognitive Intervention on Elderly People and on Patient's with Alzheimer's Disease [C] . J.J. Yanguas, C. Buiza, I. Etxeberria, International Conference on Computers Helping People with Special Needs(ICCHP 2006); 20060711-13; Linz(AT) . 2006

机译：认知干预对老年人和阿尔茨海默氏病患者疗效的随机，安慰剂对照研究
5. Acupuncture for Mild Cognitive Impairment (MCI): From Interpretation in Classics to Efficacy of Randomized Controlled Trial [D] . Kwan, Ka Lun. 2016

机译：针灸治疗轻度认知障碍（MCI）：从经典解释到随机对照试验的功效
6. The Alzheimer's disease THErapy with NEuroaid (ATHENE) study protocol: Assessing the safety and efficacy of Neuroaid II (MLC901) in patients with mild-to-moderate Alzheimer's disease stable on cholinesterase inhibitors or memantine—A randomized, double-blind, placebo-controlled trial [O] . Christopher L.H. Chen, Purabi Reang Sharma, Boon Yeow Tan, 2015

机译：NEuroaid（ATHENE）研究阿尔茨海默氏病的研究方案：评估神经碱II（MLC901）在胆碱酯酶抑制剂或美金刚稳定的轻度至中度阿尔茨海默氏病患者中的安全性和有效性-随机，双盲，安慰剂对照试用
7. Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimer's Disease and Mild Cognitive Impairment: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial [O] . Takehiko Fujino, Tatsuo Yamada, Takashi Asada, 2017

机译：口服施用缩醛磷脂治疗轻度阿尔茨海默病和轻度认知障碍患者的疗效和血浆原胶原变化：多中心，随机，双盲，安慰剂对照试验

Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimers Disease and Mild Cognitive Impairment: A Multicenter Randomized Double-blind Placebo-controlled Trial

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