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Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles

机译：禁食和进食条件下两种喹硫平缓释片在中国健康志愿者中的生物等效性以及食物对药代动力学的影响

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摘要

ObjectiveThe objectives of this study were to evaluate the bioequivalence of Quesero extended release (Quesero XR) tablets and Seroquel extended release (Seroquel XR) tablets under fasting and fed conditions and to determine the effect of food on the pharmacokinetic (PK) properties of Quesero XR or Seroquel XR in Chinese healthy volunteers.

机译：目的本研究的目的是评估禁食和进食条件下Quesero缓释（Quesero XR）片剂和Seroquel缓释（Seroquel XR）片剂的生物等效性，并确定食品对Quesero XR药代动力学（PK）特性的影响或中国健康志愿者中的Seroquel XR。

著录项

期刊名称 Drug Design Development and Therapy
作者
Xiaomei Huang; Suhua Zhang; Yanxia Ma; Heng Yang; Chuan He; Rufang Tian; Han Mei; Lipeng Liu; Bikui Zhang;
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作者单位

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年(卷),期 2019(13),-1
年度 2019
页码 255–264
总页数 10
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
quetiapine UPLC-MS/MS food effect pharmacokinetics;

机译：喹硫平;UPLC-MS / MS;食品效果;药代动力学;

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专利

1. Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles [J] . Xiaomei Huang, Suhua Zhang, Yanxia Ma, Drug Design, Development and Therapy . 2018,第4期

机译：禁食和进食条件下两种喹硫平缓释片在中国健康志愿者中的生物等效性以及食物对药代动力学的影响
2. Assessment of the bioequivalence of two formulations of clarithromycin extended-release 500-mg tablets under fasting and fed conditions: a single-dose, randomized, open-label, two-period, two-way crossover study in healthy Jordanian male volunteers. [J] . Alkhalidi BA, Tamimi JJ, Salem II, Clinical therapeutics . 2008,第10期

机译：在禁食和进食条件下评估两种制剂克拉霉素500毫克缓释制剂的生物等效性：在约旦健康的男性志愿者中进行的单剂量，随机，开放标签，两期，双向转换研究。
3. Pharmacokinetic Bioequivalence Studies of an Extended-Release Oxycodone Hydrochloride Tablet in Healthy Japanese Subjects Under Fasting and Fed Conditions Without an Opioid Antagonist [J] . Kaoru Toyama, Hidetoshi Furuie, Kana Kuroda, Drugs in R&D . 2017,第3期

机译：在没有阿片类药物拮抗剂的禁食和进食条件下，健康日本受试者中延长释放盐酸羟考酮片的药代动力学生物等效性研究
4. Pharmacokinetics of Gabapentin After Single and Repeated Dosing of Gabapentin Extended Release Tablets (G-ER) and Instant Release (IR) Tablets in Healthy Male andFemale Volunteers [C] . Toufigh Gordi, Eddie Hou, Bret Berner Controlled Release Society Annual Meeting and Exposition . 2007

机译：加巴喷丁缓释片（G-ER）和速释（IR）片在健康男性和女性志愿者中的单次和重复给药后，加巴喷丁的药代动力学
5. Development of an extended release acetaminophen-hydroxypropyl cellulose matrix tablets and evaluation of effects of polymer loading and additives on drug release kinetics [D] . Patel, Sunil 2011

机译：对乙酰氨基酚-羟丙基纤维素基质缓释片的研制以及聚合物负载量和添加剂对药物释放动力学的影响
6. Pharmacokinetics and Bioequivalence Evaluation of Two Montelukast Sodium Chewable Tablets in Healthy Chinese Volunteers Under Fasted and Fed Conditions [O] . Weihong Li, Yanrong Wang, Yingzi Pei, 2021

机译：在禁食和美联储条件下健康中国志愿者中两种蒙特利亚斯特钠咀嚼片的药代动力学和生物等值评价
7. Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles [O] . Xiaomei Huang, Suhua Zhang, Yanxia Ma, 2018

机译：在禁食和美联储条件下，中国健康志愿者中两种喹诗延长释放片的生物等效性和食物对药代动力学谱的影响

Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles

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