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The safety pharmacodynamics and pharmacokinetics of immediate-release formulation containing esomeprazole 20 mg/sodium bicarbonate 800 mg in healthy adult male

机译：含有埃索美拉唑20 mg /碳酸氢钠800 mg的速释制剂在健康成年男性中的安全性药效学和药代动力学

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BackgroundEsomeprazole is the most effective treatment for acid-related disorders and is widely used with enteric coating due to rapid degradation in the acidic environment. However, the enteric-coated formulation delays absorption and onset of action. To overcome this limitation, an immediate-release formulation containing esomeprazole 20 mg and sodium bicarbonate 800 mg (IR-ESO) was developed.

机译：背景埃索美拉唑是治疗酸相关疾病的最有效方法，由于在酸性环境中会迅速降解，因此广泛用于肠溶衣。但是，肠溶制剂延迟了吸收和作用开始。为了克服这一限制，开发了一种速释制剂，其中含有20 mg的埃索美拉唑和800 mg的碳酸氢钠（IR-ESO）。

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期刊名称 Drug Design Development and Therapy
作者
Dasohm Kim; Min Soo Park; Byung Won Yoo; Taegon Hong; Shin Jung Park; Choon Ok Kim;
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作者单位

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年(卷),期 2019(13),-1
年度 2019
页码 3151–3159
总页数 9
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
sodium bicarbonate immediate-release esomeprazole esomeprazole 24-hr pH monitoring;

机译：碳酸氢钠;速释埃索美拉唑;埃索美拉唑;24小时pH监测;

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1. The safety, pharmacodynamics, and pharmacokinetics of immediate-release formulation containing esomeprazole 20 mg/sodium bicarbonate 800 mg in healthy adult male [J] . Dasohm Kim, Min Soo Park, Byung Won Yoo, Drug Design, Development and Therapy . 2019,第InaProgress期

机译：在健康成年男性中，含埃索美拉唑20 mg /碳酸氢钠800 mg的速释制剂的安全性，药效学和药代动力学
2. Evaluation of the safety, pharmacodynamic, and pharmacokinetic effects following oral coadministration of immediate-release morphine with ethanol in healthy male participants. [J] . Beatrice Setnik, Marta Sokolowska, Franklin Johnson, Human psychopharmacology: clinical and experimental . 2014,第3期

机译：在健康男性受试者中口服速释吗啡与乙醇并用后评估安全性，药效学和药代动力学作用。
3. The pharmacokinetics, pharmacodynamics and safety of oral doses of ilaprazole 10, 20 and 40 mg and esomeprazole 40 mg in healthy subjects: A randomised, open-label crossover study [J] . ShinJ.S., LeeJ.Y., ChoK.H., Alimentary pharmacology & therapeutics. . 2014,第5期

机译：口服剂量ilaprazole 10、20和40 mg和esomeprazole 40 mg在健康受试者中的药代动力学，药效学和安全性：一项随机，开放标签的交叉研究
4. Safety, tolerability, pharmacodynamics and pharmacokinetics following single subcutaneous dosesof a teverelix depot formulation in healthy male volunteers [C] . C. MacLean, F. Larsen, R. Piechatzek, Annual meeting exposition of the Controlled Release Society . 2005

机译：在健康男性志愿者中单次皮下注射Teverelix储库制剂后的安全性，耐受性，药效动力学和药代动力学
5. Pharmacokinetic/Pharmacodynamic Analyses of Avatrombopag in Healthy Subjects and Patients with Chronic Liver Disease [D] . NOMOTO, Maiko 2019

机译：阿法曲巴帕在健康受试者和慢性肝病患者中的药代动力学/药效学分析
6. Pharmacokinetics pharmacodynamics and safety of lesinurad a selective uric acid reabsorption inhibitor in healthy adult males [O] . Zancong Shen, Colin Rowlings, Brad Kerr, 2015

机译：莱西努德（一种选择性的尿酸重吸收抑制剂）在健康成年男性中的药代动力学药效学和安全性
7. Bioequivalence Study of Two Oral-Capsule Formulations of Omeprazole 20 mg in Combination with Sodium Bicarbonate in Healthy Mexican Adult Volunteers [O] . Rosete-Reyes A, Mendoza-Tamayo G, González-Bañuelos J, 2016

机译：奥美拉唑20mg与碳酸氢钠在健康墨西哥成人志愿者中组合的两种口腔胶囊配方的生物等效研究

The safety pharmacodynamics and pharmacokinetics of immediate-release formulation containing esomeprazole 20 mg/sodium bicarbonate 800 mg in healthy adult male

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