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Role of polymorphisms of toll-like receptor (TLR) 4 TLR9 toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children

机译：Toll样受体（TLR）4TLR9toll白介素1受体结构域包含衔接蛋白（TIRAP）和FCGR2A基因多态性在布隆迪儿童疟疾易感性和严重性中的作用

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BackgroundMalaria caused by Plasmodium falciparum is one of the leading causes of human morbidity and mortality from infectious diseases, predominantly in tropical and sub-tropical countries. As genetic variations in the toll-like receptors (TLRs)-signalling pathway have been associated with either susceptibility or resistance to several infectious and inflammatory diseases, the supposition is that single nucleotide polymorphisms (SNPs) of TLR2, TLR4, TLR9, Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A could modulate malaria susceptibility and severity.

机译：背景恶性疟原虫引起的疟疾是人类传染病发病率和死亡率的主要原因之一，主要发生在热带和亚热带国家。由于Toll样受体（TLR）信号通路的遗传变异与对几种传染性和炎性疾病的易感性或耐药性有关，因此推测是TLR2，TLR4，TLR9，Toll白介素的单核苷酸多态性（SNP）。 1个受体域包含衔接蛋白（TIRAP）和FCGR2A可以调节疟疾易感性和严重性。

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期刊名称 Malaria Journal
作者
Susanna Esposito; Claudio Giuseppe Molteni; Alberto Zampiero; Elena Baggi; Anna Lavizzari; Margherita Semino; Cristina Daleno; Michela Groppo; Alessia Scala; Leonardo Terranova; Monica Miozzo; Claudio Pelucchi; Nicola Principi;
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年(卷),期 2012(11),-1
年度 2012
页码 196
总页数 8
原文格式 PDF
正文语种
中图分类寄生动物、寄生虫学;医学寄生虫学;
关键词
Children cerebral malaria FCGR2A malaria SNPs toll-like receptors TIRAP TLR4 TLR9 uncomplicated malaria.;

机译：儿童;脑型疟疾;FCGR2A;疟疾;SNP;通行费样受体;TIRAP;TLR4;TLR9;单纯性疟疾。;

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1. Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children [J] . Susanna Esposito, Claudio Giuseppe Molteni, Alberto Zampiero, Malaria Journal . 2012,第S1期

机译：Toll样受体（TLR）4，TLR9，toll白介素1受体结构域包含衔接蛋白（TIRAP）和FCGR2A基因多态性在布隆迪儿童疟疾易感性和严重性中的作用
2. Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. [J] . Ghose R, Guo T, Vallejo JG, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2011,第5期

机译：Toll-白介素1受体域的适配器蛋白在Toll样受体2介导的肝细胞因子和药物代谢酶基因表达的调节中的差异作用。
3. Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. [J] . Ghose R, White D, Guo T, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2008,第1期

机译：Toll样受体4信号传导对肝药物代谢酶基因的调节独立于包含Toll-白介素1受体域的衔接蛋白。
4. Increased Expression of Toll-Like Receptor (TLR)4 in the Nasal Mucosa and Peripheral Blood of Children: Role In Protection Against Allergic Inflammation [C] . M.K. Tulic, P. Fiset, H. Zheng Asia Pacific Congress of Allergology and Clinical Immunology . 2004

机译：在鼻粘膜和儿童周围血液中增加了Toll样受体（TLR）4的表达：在过敏性炎症的保护中的作用
5. Porphyromonas gingivalis major and minor fimbria-induced interleukin-8 production by human aortic endothelial cells: The role of Toll-like receptors (TLR)2 and TLR4. [D] . Davey, Michael Thomas. 2007

机译：人主动脉内皮细胞牙龈卟啉单胞菌主要和次要的菌毛诱导白细胞介素8的产生：Toll样受体（TLR）2和TLR4的作用。
6. Differential Role of Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein in Toll-Like Receptor 2-Mediated Regulation of Gene Expression of Hepatic Cytokines and Drug-Metabolizing Enzymes [O] . Romi Ghose, Tao Guo, Jesus G. Vallejo, -1

机译：Toll-白介素1受体域适配器蛋白在Toll受体2介导的肝细胞因子和药物代谢酶基因表达调控中的差异作用。
7. Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children [O] . 2012

机译：Toll样受体（TLR）4，TLR9，toll白介素1受体结构域包含衔接蛋白（TIRAP）和FCGR2A基因多态性在布隆迪儿童疟疾易感性和严重性中的作用

Role of polymorphisms of toll-like receptor (TLR) 4 TLR9 toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children

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