Tumor Treating Fields (TTFields) in combination with chemotherapy and/or radiotherapy have been clinically reported to provide prolonged overall survival in glioblastoma patients. Alternating electric fields with frequencies of 100~300 kHz and magnitudes of 1~3 V/cm are shown to suppress the growth of cancer cells via interactions with polar molecules within dividing cells. Since it is difficult to directly measure the electric fields inside the brain, simulation models of the human head provide a useful tool for predicting the electric field distribution. In the present study, a three-dimensional finite element head model consisting of the scalp, the skull, the dura, the cerebrospinal fluid, and the brain was built to study the electric field distribution under various applied potentials and electrode configurations. For simplicity, a direct-current electric field was used in the simulation. The total power dissipation and temperature elevation due to Joule heating in different head tissues were also evaluated. Based on the results, some guidelines are obtained in designing the electrode configuration for personalized glioblastoma electrotherapy.
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机译：临床上已报道肿瘤治疗领域（TTFields）与化学疗法和/或放射疗法相结合可在胶质母细胞瘤患者中提供更长的总生存期。频率为100〜300 kHz，幅度为1〜3 V / cm的交变电场通过与分裂细胞内的极性分子相互作用来抑制癌细胞的生长。由于很难直接测量大脑内部的电场，因此人体头部的仿真模型为预测电场分布提供了有用的工具。在本研究中，建立了由头皮，头骨，硬脑膜，脑脊髓液和大脑组成的三维有限元头部模型，以研究在各种施加电势和电极配置下的电场分布。为了简单起见，在仿真中使用了直流电场。还评估了不同头部组织中因焦耳热引起的总功耗和温度升高。根据结果，在设计个性化胶质母细胞瘤电疗法的电极配置时可获得一些指导。
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