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A village level cluster-randomized entomological evaluation of combination long-lasting insecticidal nets containing pyrethroid plus PBO synergist in Southern Mali

机译:马里南部含拟除虫菊酯和PBO增效剂的长效组合杀虫网的村级集群随机昆虫学评估

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摘要

BackgroundThere is growing concern that malaria vector resistance to pyrethroid insecticides may reduce the effectiveness of long-lasting insecticidal nets (LLINs). Combination LLINs are designed to control susceptible and pyrethroid-resistant mosquito populations through a mixture of pyrethroid with piperonyl butoxide (PBO) synergist. A cluster randomized trial with entomology outcome measures was conducted in Mali to determine the added benefit over mono-treated pyrethroid predecessors. Four LLIN treatments; permethrin + PBO, permethrin, deltamethrin + PBO, and deltamethrin, were randomly allocated to four villages each (16 villages total) and distributed to cover every sleeping place. Entomological monitoring of indoor Anopheles resting densities, host preference, vector longevity, and sporozoite rates were monitored every 2 months over 2 years in 2014 and 2015.
机译:背景技术疟疾媒介对拟除虫菊酯类杀虫剂的抗药性可能会降低长效杀虫网(LLIN)的效力,这引起了越来越多的关注。 LLIN的组合旨在通过拟除虫菊酯与胡椒基丁醇(PBO)增效剂的混合物来控制易感和拟除虫菊酯的蚊子种群。在马里进行了一项采用昆虫学结果测量的随机分组试验,以确定与单药治疗的拟除虫菊酯前体药物相比的额外益处。四种LLIN治疗;氯菊酯+ PBO,氯菊酯,溴氰菊酯+ PBO和溴氰菊酯被随机分配到四个村庄(总共16个村庄),并分布在每个睡觉的地方。 2014年和2015年每2个月对室内按蚊的静息密度,寄主偏好,媒介寿命和子孢子率进行昆虫学监测。

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