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首页> 美国卫生研究院文献>Pilot and Feasibility Studies >A protocol for a randomised controlled double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine Learning and Memory in Epilepsy (FLAME trial)
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A protocol for a randomised controlled double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine Learning and Memory in Epilepsy (FLAME trial)

机译：一项随机对照双盲可行性研究的方案研究氟西汀治疗改善中颞叶癫痫患者的记忆和学习障碍：氟西汀癫痫的学习和记忆（FLAME试验）

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BackgroundPeople with temporal lobe epilepsy (TLE) report significant problems with learning and memory. There are no effective therapies for combatting these problems in people with TLE, resulting in an unmet therapeutic need. The lack of treatment is, in part, due to a poor understanding of the neurobiology underlying these memory deficits. We know that hippocampal neurogenesis, a process believed to be important in learning and memory formation, is permanently reduced in chronic TLE, and this may go some way to explain the learning and memory impairments seen in people with TLE.The common anti-depressant drug fluoxetine has been shown to stimulate neurogenesis both in the healthy brain and in neurological diseases where neurogenesis is impaired. In an animal model of TLE, administration of fluoxetine was found to restore neurogenesis and improve learning on a complex spatial navigational task. We now want to test this effect in humans by investigating whether administration of fluoxetine to people with TLE can improve learning and memory.
机译：背景颞叶癫痫（TLE）的人们报告了学习和记忆方面的重大问题。目前尚无有效的疗法可解决TLE患者的这些问题，从而导致治疗需求未得到满足。缺乏治疗的部分原因是对这些记忆缺陷背后的神经生物学了解不足。我们知道，慢性TLE永久性减少了海马神经发生，这一过程被认为对学习和记忆形成很重要，而这可能可以用某种方式解释在TLE患者中出现的学习和记忆障碍。氟西汀已被证明可以在健康的大脑和神经发生受损的神经系统疾病中刺激神经发生。在TLE的动物模型中，发现氟西汀的给药可恢复神经发生并改善复杂空间导航任务的学习。现在，我们希望通过研究对TLE患者使用氟西汀是否可以改善学习和记忆能力，从而在人类中测试这种效果。

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