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首页> 美国卫生研究院文献>The Libyan Journal of Medicine >In vivo effects of Faizol Ubat Batuk a herbal product on aminopyrine metabolism in rat hepatocytes
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In vivo effects of Faizol Ubat Batuk a herbal product on aminopyrine metabolism in rat hepatocytes

机译：草药产品Faizol Ubat Batuk对大鼠肝细胞中氨基比林代谢的体内作用

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摘要

Traditional medicines, in particular herbal products, have been used abundantly over the years in curing several diseases. Pharmacological interactions of herbal products with modern drugs, however, remain to some extent unknown. Herein, we examined whether co-administration of Faizol Ubat Batuk (FUB), a mixture of aqueous extract of different plants, modifies the metabolism of aminopyrine, a conventional analgesic drug, in rat liver. We used rat hepatocytes outfitted by collagenase perfusion technique. Determination of aminopyrine n-demethylase activity was performed using the Nash colorimetric method, by measuring the amount of formaldehyde produced. Compared to control treatment, FUB significantly increased the hepatic metabolism of aminopyrine in healthy adult male rats. In contrast, the hepatic metabolism of aminopyrine in adult female rats was decreased. Besides, a biphasic effect in n-demethylase activity was observed in young male rats treated with FUB. In a subsequent experiment, FUB did not change the metabolism of aminopyrine in streptozotocin (STZ)-diabetic adult male rats. In conclusion, administration of FUB could affect phase I aminopyrine metabolism in rat heptocytes. In addition, the effects of FUB on hepatic n-demethylase activity were gender and disease dependent.
机译：多年来，传统药物特别是草药产品已被广泛用于治疗多种疾病。然而，草药产品与现代药物的药理相互作用在某种程度上仍然未知。本文中，我们研究了不同植物的水提取物混合物Faizol Ubat Batuk（FUB）的共同给药是否能改善大鼠肝脏中传统镇痛药氨比林的代谢。我们使用了胶原酶灌注技术装备的大鼠肝细胞。使用纳什比色法，通过测量产生的甲醛量来确定氨基比林正-脱甲基酶活性。与对照治疗相比，FUB显着增加了健康成年雄性大鼠中氨基比林的肝代谢。相反，成年雌性大鼠的氨基比林的肝代谢降低。此外，在用FUB处理的幼小雄性大鼠中，观察到了n-脱甲基酶活性的两相作用。在随后的实验中，FUB并未改变链脲佐菌素（STZ）糖尿病成年雄性大鼠中氨基比林的代谢。总之，施用FUB可能会影响大鼠肝细胞的I期氨基比林代谢。此外，FUB对肝脏正-脱甲基酶活性的影响与性别和疾病有关。

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