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首页> 美国卫生研究院文献>Toxicological Research >The Simplest Flowchart Stating the Mechanisms for Organic Xenobiotics-induced Toxicity: Can it Possibly be Accepted as a Central Dogma for Toxic Mechanisms?
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The Simplest Flowchart Stating the Mechanisms for Organic Xenobiotics-induced Toxicity: Can it Possibly be Accepted as a Central Dogma for Toxic Mechanisms?

机译：最简单的流程图阐明了有机异源生物诱导的毒性机制：是否可能被接受为毒性机制的中心教条？

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Xenobiotics causing a variety of toxicity in biological systems could be classified as two types, inorganic and organic chemicals. It is estimated that the organic xenobiotics are responsible for approximately 80~90% of chemical-induced toxicity in human population. In the class for toxicology, we have encountered some difficulties in explaining the mechanisms of toxicity caused especially by organic chemicals. Here, a simple flowchart was introduced for explaining the mechanism of toxicity caused by organic xenobiotics, as the central dogma of molecular biology. This flowchart, referred to as a central dogma, was described based on a view of various aspects as follows: direct-acting chemicals vs. indirect-acting chemicals, cytochrome P450-dependent vs. cytochrome P450-independent biotransformation, reactive intermediates, reactivation, toxicokinetics vs. toxicodynamics, and reversibility vs. irreversibility. Thus, the primary objective of this flowchart is to help better understanding of the organic xenobiotics-induced toxic mechanisms, providing a major pathway for toxicity occurring in biological systems.
机译：在生物系统中引起多种毒性的异生物素可以分为无机化学物质和有机化学物质两种。据估计，有机异源生物在人类中约占化学诱导毒性的80％至90％。在毒理学课上，我们在解释特别是有机化学物质引起的毒性机理时遇到了一些困难。在这里，介绍了一个简单的流程图，用于解释作为分子生物学中心教条的有机异源生物引起的毒性机理。基于以下各个方面对这个流程图（称为中央教条）进行了描述：直接作用化学品与间接作用化学品，细胞色素P450依赖性与细胞色素P450无关的生物转化，反应性中间体，重新活化，毒物动力学与毒物动力学，以及可逆性与不可逆性。因此，该流程图的主要目的是帮助更好地了解有机异种生物诱导的毒性机制，为生物系统中发生的毒性提供主要途径。

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