• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>MethodsX >An improved method for measuring metaldehyde in surface water using liquid chromatography tandem mass spectrometry
【2h】

An improved method for measuring metaldehyde in surface water using liquid chromatography tandem mass spectrometry

机译：液相色谱-串联质谱法测定地表水中甲醛的改进方法

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

class="kwd-title">Method name: An improved method for measuring metaldehyde in surface water using liquid chromatography tandem mass spectrometry class="kwd-title">Keywords: Metaldehyde, Surface water, Liquid chromatography–tandem mass spectrometry, On-line enrichment, Methylamine, Molluscicide class="head no_bottom_margin" id="abs0010title">AbstractThe molluscicide metaldehyde (2,4,6,8-tetramethyl-1,3,5,7-tetraoxocanemetacetaldehyde) is an emerging pollutant. It is frequently detected in surface waters, often above the European Community Drinking Water Directive limit of 0.1 μg/L for a single pesticide. Gas chromatography mass spectrometry (GC–MS) can be used to determine metaldehyde in environmental waters, but this method requires time consuming extraction techniques prior to instrumental analysis. Use of liquid chromatography-tandem mass spectrometry (LC–MS/MS) can overcome this problem. We describe a novel LC–MS/MS method, using a methylamine mobile phase additive, coupled with on-line sample enrichment that allows for the rapid and sensitive measurement of metaldehyde in surface water. Only the methylamine adduct of metaldehyde was formed with other unwanted alkali metal adducts and dimers being suppressed. As considerably less collision energy is required to fragment the methylamine adduct, a five-fold improvement in method sensitivity, compared to a previous method using an ammonium acetate buffer mobile phase was achieved. This new approach offers: class="first-line-outdent">
  • • A validated method that meets regulatory requirements for the determination of metaldehyde in surface water.
  • • Improved reliability of quantification over existing LC–MS/MS methods by using stable precursor ions for multiple reaction monitoring.
  • • Low limits of quantification for tap water (4 ng/L) and river water (20 ng/L) using only 800 μL of sample; recoveries > 97%.
    • 机译：<！-fig ft0-> <！-fig @ position =“ anchor” mode =文章f4-> <！-fig mode =“ anchred” f5-> <！-fig / graphic | fig / alternatives / graphic mode =“ anchored” m1-> class =“ kwd-title”>方法名称：一种使用液相色谱串联质谱法测定地表水中甲醛的改进方法 class =“ kwd-title“>关键字：甲醛，地表水，液相色谱-串联质谱，在线富集，甲胺，杀软体动物剂 class =” head no_bottom_margin“ id =” abs0010title“>摘要杀软体动物的甲醛（2,4,6,8-四甲基-1,3,5,7-四氧杂环丁烷甲醛）是一种新兴污染物。它经常在地表水中检测到，通常超过一种农药对欧共体饮用水指令的限制0.1μg/ L。气相色谱质谱法（GC-MS）可用于测定环境水中的甲醛，但是这种方法在仪器分析之前需要耗时的萃取技术。使用液相色谱-串联质谱（LC-MS / MS）可以解决此问题。我们描述了一种新型的LC-MS / MS方法，该方法使用甲胺流动相添加剂以及在线样品富集功能，可以快速，灵敏地测量地表水中的甲醛。仅形成了乙醛的甲胺加合物，而其他不需要的碱金属加合物和二聚体被抑制。由于裂解甲胺加合物所需的碰撞能量要少得多，因此与以前使用乙酸铵缓冲液流动相的方法相比，方法灵敏度提高了五倍。这种新方法提供了： class =“ first-line-outdent”> <！-list-behavior =简单的前缀-word = mark-type = none max-label-size = 9->
  • •一种经过验证的方法，可以满足测定地表水中甲醛的法规要求。
  • •通过使用稳定的前体离子，与现有的LC-MS / MS方法相比，定量的可靠性更高
  • •仅使用800μL的样品，对自来水（4 ng / L）和河水（20 ng / L）的定量下限低；回收率> 97％。

    • 著录项

    相似文献

    • 外文文献
    • 中文文献
    • 专利
    代理获取

    客服邮箱：kefu@zhangqiaokeyan.com

    京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

    • 客服微信

    • 服务号