• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Journal of Microbiology Biology Education >Three-Dimensional Visualizations in Teaching Genomics and Bioinformatics: Mutations in HIV Envelope Proteins and Their Consequences for Vaccine Design
【2h】

Three-Dimensional Visualizations in Teaching Genomics and Bioinformatics: Mutations in HIV Envelope Proteins and Their Consequences for Vaccine Design

机译：在基因组学和生物信息学教学中的三维可视化：HIV包膜蛋白的突变及其疫苗设计的后果

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This project addresses the need to provide a visual context to teach the practical applications of genome sequencing and bioinformatics. Present-day research relies on indirect visualization techniques (e.g., fluorescence-labeling of DNA in sequencing reactions) and sophisticated computer analysis. Such methods are impractical and prohibitively expensive for laboratory classes. More importantly, there is a need for curriculum resources that visually demonstrate the application of genome sequence information rather than the DNA sequencing methodology itself. This project is a computer-based lesson plan that engages students in collaborative, problem-based learning. The specific example focuses on approaches to Human Immunodeficiency Virus-1 (HIV-1) vaccine design based on HIV-1 genome sequences using a case study. Students performed comparative alignments of variant HIV-1 sequences available from a public database. Students then examined the consequences of HIV-1 mutations by applying the alignments to three-dimensional images of the HIV-1 envelope protein structure, thus visualizing the implications for applications such as vaccine design. The lesson enhances problem solving through the application of one type of information (genomic or protein sequence) into concrete visual conceptualizations. Assessment of student comprehension and problem-solving ability revealed marked improvement after the computer tutorial. Furthermore, contextual presentation of these concepts within a case study resulted in student responses that demonstrated higher levels of cognitive ability than was expected by the instructor.
机译：该项目满足了提供可视化背景来教授基因组测序和生物信息学实际应用的需求。目前的研究依赖于间接可视化技术（例如，测序反应中DNA的荧光标记）和复杂的计算机分析。这样的方法是不切实际的，并且对于实验室课程来说是昂贵的。更重要的是，需要课程资源来直观地证明基因组序列信息的应用，而不是DNA测序方法本身。该项目是一个基于计算机的课程计划，旨在使学生参与基于问题的协作学习。具体实例集中在案例研究的基础上，基于HIV-1基因组序列的人类免疫缺陷病毒1（HIV-1）疫苗设计方法。学生进行了从公共数据库获得的HIV-1变异序列的比较比对。然后，学生通过将比对应用于HIV-1包膜蛋白结构的三维图像来检查HIV-1突变的后果，从而可视化其对疫苗设计等应用的影响。本课程通过将一种类型的信息（基因组或蛋白质序列）应用到具体的视觉概念化中，从而增强了解决问题的能力。计算机辅导后，对学生的理解力和解决问题能力的评估显示出明显的进步。此外，案例研究中对这些概念的上下文介绍导致学生的回答显示出比教师期望的更高的认知能力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号