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首页> 美国卫生研究院文献>Middle East Journal of Digestive Diseases >A Comprehensive Look at Irritable Bowel Syndrome and its Associated Factors Considering the Rome IV Criteria: A Penalized Smoothly Clipped Absolute Deviation Regression Approach in the Pars Cohort Study
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A Comprehensive Look at Irritable Bowel Syndrome and its Associated Factors Considering the Rome IV Criteria: A Penalized Smoothly Clipped Absolute Deviation Regression Approach in the Pars Cohort Study

机译：综合考虑罗马IV标准的肠易激综合征及其相关因素的全面研究：帕尔斯队列研究中的一种惩罚性平滑截断绝对偏差回归方法

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BACKGROUND After the introduction of the Rome IV criteria for the diagnosis of irritable bowel syndrome (IBS), studies on the clinical significance of the new criteria in the settings of a large study has been scarce. >Objective: Herein we used the infrastructures provided by one the largest cohort studies in Iran to evaluate the epidemiological features related to IBS. METHODS A total of 9264 participants, were enrolled in the initial registry. Diagnosis of IBS was done using the Rome IV criteria. Individuals with IBS were compared with a control group. Since the study included a large sample size of patients, we used the penalized smoothly clipped absolute deviation (SCAD) regression analysis to construct a model for the evaluation of factors associated with IBS. RESULTS Overall, data of 9163 participants entered the final analysis. In total, 1067 (11.6%) individualswere diagnosed with IBS, among which 57 (5.3%) were diarrhea dominant (IBS-D), 380 (35.6%)were constipation dominant (IBS-C), and 630 (59%) did not mention having any of the two (IBS-U).In the regression model, back pain/arthralgia (OR: 1.98, 95% CI: 1.65 - 2.40), insomnia (OR:1.65, 95% CI: 1.40 - 1.93), depression (OR: 1.64, 95% CI: 1.38 - 1.95), female sex (OR: 1.58, 95%CI: 1.27 - 1.96), anxiety (OR: 1.43, 95% CI: 1.21 - 1.69), and being married (OR: 1.23, 95% CI:1.03 - 1.48), were associated with higher rates of IBS. We found that IBS prevalence displays a peakat the age of 41 years for both men and women.CONCLUSIONThe present study provides a background for follow-up studies to be conducted in order toevaluate causality between IBS and some major diseases such as liver disease. We also found thatopium use, although not statistically significant, in addition to sex, education, back/joint pain,depression, insomnia, anxiety, and marital status might be a contributing factor in IBS.
机译：背景技术在引入罗马IV诊断肠易激综合症（IBS）的标准之后，对于新标准在大型研究机构中的临床意义的研究就很少了。 >目的：本文中，我们使用了伊朗最大的一项队列研究提供的基础设施来评估与IBS相关的流行病学特征。方法最初的注册表中共有9264名参与者。 IBS的诊断使用Rome IV标准进行。将IBS患者与对照组进行比较。由于该研究包括大量患者样本，因此我们使用了惩罚性平滑限幅绝对偏差（SCAD）回归分析来构建模型，用于评估与IBS相关的因素。结果总体而言，9163名参与者的数据进入了最终分析。总计1067（11.6％）个人被诊断患有IBS，其中腹泻为主（IBS-D）57（5.3％），380（35.6％）便秘占主导地位（IBS-C），而630（59％）没有提及两者兼有（IBS-U）。在回归模型中，腰痛/关节痛（OR：1.98，95％CI：1.65-2.40），失眠（OR：1.65，95％CI：1.40-1.93），抑郁症（OR：1.64，95％CI：1.38-1.95），女性（OR：1.58，95％CI：1.27-1.96），焦虑（OR：1.43、95％CI：1.21-1.69）和已婚（OR：1.23、95％CI：1.03-1.48）与较高的IBS发生率相关。我们发现IBS的患病率达到峰值男女年龄均在41岁。结论本研究为进行后续研究提供了背景，以便评估IBS与某些主要疾病（例如肝脏疾病）之间的因果关系。我们还发现鸦片的使用，尽管没有统计学意义，除了性别，教育程度，背部/关节疼痛，抑郁，失眠，焦虑和婚姻状况可能是IBS的一个促成因素。

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