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RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?

机译：RASSF信号传导和DNA损伤：监测基因组的完整性？

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摘要

The RASSF family of proteins has been extensively studied in terms of their genetics, structure and function. One of the functions that has been increasingly studied is the role of the RASSF proteins in the DNA damage response. Surprisingly, this research, which encompasses both the classical and N-terminal RASSF proteins, has revealed an involvement of the RASSFs in oncogenic pathways as well as the more familiar tumour suppressor pathways usually associated with the RASSF family members. The most studied protein with respect to DNA damage is RASSF1A, which has been shown, not only to be activated by ATM, a major regulator of the DNA damage response, but also to bind to and activate a number of different pathways which all lead to and feedback from the guardian of the genome, p53. In this review we discuss the latest research linking the RASSF proteins to DNA damage signalling and maintenance of genomic integrity and look at how this knowledge is being utilised in the clinic to enhance the effectiveness of traditional cancer therapies such as radiotherapy.
机译：RASSF家族的蛋白质已经在遗传学，结构和功能方面进行了广泛的研究。越来越多的功能之一是RASSF蛋白在DNA损伤反应中的作用。出乎意料的是，这项涵盖了经典和N末端RASSF蛋白的研究揭示了RASSFs参与了致癌途径以及通常与RASSF家族成员相关的更为熟悉的肿瘤抑制途径。关于DNA损伤的研究最多的蛋白质是RASSF1A，它不仅被DNA应答反应的主要调节剂ATM激活，而且还结合并激活了许多不同的途径，这些途径均导致以及来自基因组守护者p53的反馈。在这篇综述中，我们讨论了将RASSF蛋白与DNA损伤信号传导和基因组完整性维持联系起来的最新研究，并探讨了如何在临床上利用这一知识来增强传统癌症疗法（例如放射疗法）的有效性。

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