Nucleotide Excision Repair in Caenorhabditis elegans

机译：秀丽隐杆线虫的核苷酸切除修复

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Nucleotide excision repair (NER) plays an essential role in many organisms across life domains to preserve and faithfully transmit DNA to the next generation. In humans, NER is essential to prevent DNA damage-induced mutation accumulation and cell death leading to cancer and aging. NER is a versatile DNA repair pathway that repairs many types of DNA damage which distort the DNA helix, such as those induced by solar UV light. A detailed molecular model of the NER pathway has emerged from in vitro and live cell experiments, particularly using model systems such as bacteria, yeast, and mammalian cell cultures. In recent years, the versatility of the nematode C. elegans to study DNA damage response (DDR) mechanisms including NER has become increasingly clear. In particular, C. elegans seems to be a convenient tool to study NER during the UV response in vivo, to analyze this process in the context of a developing and multicellular organism, and to perform genetic screening. Here, we will discuss current knowledge gained from the use of C. elegans to study NER and the response to UV-induced DNA damage.

机译：核苷酸切除修复（NER）在跨生命域的许多生物中起着至关重要的作用，以保护DNA并将其忠实地传递给下一代。在人类中，NER对于防止DNA损伤引起的突变积累和导致癌症和衰老的细胞死亡至关重要。 NER是一种通用的DNA修复途径，可修复许多类型的DNA损伤，这些损伤会扭曲DNA螺旋，例如由太阳紫外线引起的损伤。 NER通路的详细分子模型已经从体外和活细胞实验中获得，特别是使用诸如细菌，酵母和哺乳动物细胞培养物的模型系统。近年来，线虫秀丽隐杆线虫在研究包括NER在内的DNA损伤反应（DDR）机制方面的多功能性变得越来越明显。特别地，秀丽隐杆线虫似乎是研究体内紫外线反应期间的NER，在发育中的多细胞生物的背景下分析该过程以及进行基因筛选的便捷工具。在这里，我们将讨论通过使用秀丽隐杆线虫研究NER和对UV诱导的DNA损伤的响应而获得的最新知识。

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期刊名称 Molecular Biology International
作者
Hannes Lans; Wim Vermeulen;
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年(卷),期 2011(2011),-1
年度 2011
页码 542795
总页数 12
原文格式 PDF
正文语种
中图分类分子生物学;
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专利

1. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. [J] . Boyd WA, Crocker TL, Rodriguez A Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2010,第1a2期

机译：核苷酸切除修复基因在秀丽隐杆线虫体细胞组织中低水平表达且不可检测地诱导，但是其功能是紫外线暴露后正常成年生活所必需的。
2. Nucleotide excision repair and the degradation of RNA pol II by the Caenorhabditis elegans XPA and Rsp5 orthologues, RAD-3 and WWP-1. [J] . Astin JW, ONeil NJ, Kuwabara PE DNA repair . 2008,第2期

机译：秀丽隐杆线虫XPA和Rsp5直向同源物RAD-3和WWP-1的核苷酸切除修复和RNA pol II的降解。
3. The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans. [J] . Stergiou L, Doukoumetzidis K, Sendoel A, Cell death and differentiation . 2007,第6期

机译：紫外线切除诱导秀丽隐杆线虫的细胞凋亡需要核苷酸切除修复途径。
4. Polymorphisms of Genes Related to Nucleotide Excision Repair and Cell Cycle Pathways, Arsenic Exposure, and Bladder Cancer [C] . Ya-Yun Cheng, How-Ran Guo Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：与核苷酸切除修复和细胞周期途径，砷暴露和膀胱癌相关的基因的多态性
5. Base Excision Repair (BER) and Nucleotide Excision Repair (NER) of both natural and synthetic nucleotides. [D] . McKibbin, Paige Lorraine. 2012

机译：天然和合成核苷酸的碱基切除修复（BER）和核苷酸切除修复（NER）。
6. Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans [O] . Joel N Meyer, Windy A Boyd, Gregory A Azzam, 2007

机译：秀丽隐杆线虫的核苷酸切除修复能力下降
7. Nucleotide Excision Repair, XPA-1, and the Translesion Synthesis Complex, POLZ1 and REV-1, Are Critical for Interstrand Cross-Link Repair in Caenorhabditis elegans Germ Cells [O] . -1

机译：核苷酸切除修复，XPA-1和翻转合成复合物，POLZ1和Rev-1对Caenorhabdiselciss生殖细胞中的Interstrand Cross-Link修复至关重要

Nucleotide Excision Repair in Caenorhabditis elegans

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