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Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders

机译：小鼠缺乏BRINP1会导致海马神经发生增加以及与人类精神疾病相关的行为改变

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BackgroundWe have previously identified BRINP (BMP/RA-inducible neural-specific protein-1, 2, 3) family genes that possess the ability to suppress cell cycle progression in neural stem cells. Of the three family members, BRINP1 is the most highly expressed in various brain regions, including the hippocampus, in adult mice and its expression in dentate gyrus (DG) is markedly induced by neural activity. In the present study, we generated BRINP1-deficient (KO) mice to clarify the physiological functions of BRINP1 in the nervous system.

机译：背景我们之前已经确定了BRINP（BMP / RA诱导的神经特异性蛋白1、2、3）家族基因，它们具有抑制神经干细胞中细胞周期进程的能力。在这三个家族成员中，BRINP1在成年小鼠的各个大脑区域（包括海马体）中表达最高，并且其在齿状回（DG）中的表达明显受到神经活动的诱导。在本研究中，我们生成了BRINP1缺陷（KO）小鼠来阐明BRINP1在神经系统中的生理功能。

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期刊名称 Molecular Brain
作者
Miwako Kobayashi; Toshiyuki Nakatani; Toshiaki Koda; Ken-ichi Matsumoto; Ryosuke Ozaki; Natsuki Mochida; Keizo Takao; Tsuyoshi Miyakawa; Ichiro Matsuoka;
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作者单位

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年(卷),期 2014(7),-1
年度 2014
页码 12
总页数 16
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
Hippocampal neurogenesis Interneuron Behavior Psychiatric disorder;

机译：海马神经发生;中间神经元;行为;精神病;

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专利

1. Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders [J] . Miwako Kobayashi, Toshiyuki Nakatani, Toshiaki Koda, Molecular brain . 2014,第1期

机译：小鼠缺乏BRINP1会导致海马神经发生增加以及与人类精神疾病相关的行为改变
2. Src deficient mice demonstrate behavioral and electrophysiological alterations relevant to psychiatric and developmental disease [J] . Ward Katelyn R., Featherstone Robert E., Naschek Melissa J., Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal . 2019,第期

机译：SRC缺陷小鼠证明与精神病和发育疾病相关的行为和电生理改变
3. Lovastatin Prevents Depressive Behaviors and Increased Hippocampal Neurogenesis in Streptozotocin-Induced Diabetic Mice [J] . Tang Cong-Rong, Yu Xu-Ben, Zhang Hai-Na, Pharmacology: International Journal of Experimental and Clinical Pharmacology . 2020,第5a6期

机译：Lovastatin可防止抑郁行为和血管型诱导的糖尿病小鼠中的海马神经发生增加
4. Plant Compound Curcumin Increased the Expression of MAP2 in Hippocampal Neurons of APPswe/PS1dE9 Double Transgenic Mice [C] . Dan Li, Chen Wang, Song Tan, International Conference on Chemical Engineering and Advanced Materials . 2013

机译：植物化合物姜黄素增加了Appswe / ps1de9双转基因小鼠的海马神经元的Map2表达
5. Engrailed-2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. [D] . Cheh, Michelle A. 2007

机译：Engrailed-2基因敲除小鼠表现出与自闭症谱系障碍有关的神经行为和神经化学改变。
6. Correction: Behavioral and synaptic alterations relevant to obsessivecompulsive disorder in mice with increased EAAT3 expression [O] . Claudia Delgado-Acevedo, Sebastián F. Estay, Anna K. Radke, 2019

机译：更正：与强迫症有关的行为和突触改变与EAAT3表达增加的小鼠
7. Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders [O] . Miwako Kobayashi, Toshiyuki Nakatani, Toshiaki Koda, 2014

机译：小鼠缺乏BRINP1会导致海马神经发生增加以及与人类精神疾病相关的行为改变

Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders

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