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首页> 美国卫生研究院文献>The Korean Journal of Physiology Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology >Ginsenosides Have a Suppressive Effect on c-Fos Expression in Brain and Reduce Cardiovascular Responses Increased by Noxious Stimulation to the Rat Tooth
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Ginsenosides Have a Suppressive Effect on c-Fos Expression in Brain and Reduce Cardiovascular Responses Increased by Noxious Stimulation to the Rat Tooth

机译：人参皂甙对脑内c-Fos表达具有抑制作用并减少有害刺激对大鼠牙齿的刺激而增加的心血管反应

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The purpose of this study is to investigate the antinociceptive effects of ginsenosides on toothache. c-Fos immunoreactive (IR) neurons were examined after noxious intrapulpal stimulation (NS) by intrapulpal injection of 2 M KCl into upper and lower incisor pulps exposed by bone cutter in Sprague Dawley rats. The number of Fos-IR neurons was increased in the trigeminal subnucleus caudalis (Vc) and the transitional region between Vc and subnucleus interpolaris (Vi) by NS to tooth. The intradental NS raised arterial blood pressure (BP) and heart rate (HR). The number of Fos-IR neurons was also enhanced in thalamic ventral posteromedial nucleus (VPMN) and centrolateral nucleus (CLN) by NS to tooth. The intradental NS increased the number of Fos-IR neurons in the nucleus tractus solitarius (NTS) and rostral ventrolateral medulla (RVLM), hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN), central cardiovascular regulation centers. Ginsenosides reduced the number of c-Fos-IR increased by NS to tooth in the trigeminal Vc and thalamic VPMN and CLN. Naloxone, an opioid antagonist, did not block the effect of ginsenoside on the number of Fos-IR neurons enhanced by NS to tooth in the trigeminal Vc and thalamic VPMN and CLN. Ginsenosides ameliorated arterial BP and HR raised by NS to tooth and reduced the number of Fos-IR neurons increased by NS to tooth in the NTS, RVLM, hypothalamic SON, and PVN. These results suggest that ginsenosides have an antinociceptive effect on toothache through non-opioid system and attenuates BP and HR increased by NS to tooth.
机译：这项研究的目的是研究人参皂甙对牙痛的镇痛作用。在Sprague Dawley大鼠中，通过向骨切刀暴露的上下切牙髓内注射2 M KCl向肺内注射有害的肺内刺激（NS）后，检查c-Fos免疫反应（IR）神经元。通过NS到牙齿，在三叉神经尾核（Vc）以及Vc和极间亚核（Vi）之间的过渡区域，Fos-IR神经元的数量增加。牙内NS升高动脉血压（BP）和心率（HR）。 NS对牙齿的丘脑腹膜后核（VPMN）和中央外侧核（CLN）的Fos-IR神经元数量也有所增加。牙内NS增加了孤束核（NTS）和延髓腹侧延髓（RVLM），下丘脑上视核（SON）和室旁核（PVN），中央心血管调节中心的Fos-IR神经元的数量。人参皂甙减少了三叉神经Vc和丘脑VPMN和CLN中NS增高的c-Fos-IR数量。阿片样物质拮抗剂纳洛酮没有阻止人参皂苷对三叉神经Vc和丘脑VPMN和CLN中NS增强的Fos-IR神经元数量的影响。人参皂苷改善了NS在牙齿NTS，RVLM，下丘脑SON和PVN中引起的对牙齿的动脉BP和HR，并减少了NS对牙齿的Fos-IR神经元数量。这些结果表明人参皂苷通过非阿片类药物系统对牙痛具有镇痛作用，并减轻了NS对牙齿所增加的BP和HR。

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