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A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins.

机译：在精子发生和假想椎间盘形态发生过程中表达的果蝇圆形体转录物编码的蛋白质类似于人Rac GTPase激活（racGAP）蛋白质。

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摘要

The rotund (rn) locus of Drosophila melanogaster at cytogenetic position 84D3,4 has been isolated and cloned on the basis of the mutant phenotype: an absence of structures in the subdistal regions of the appendages. The shortened appendages are the consequence of a localized cell death in the imaginal discs, precursors of the adult appendages. Physical characterization of the rn locus has demonstrated that it is relatively large, occupying a minimum of 50 kb. There are two major transcripts of 1.7 kb (m1.7) and 5.3 kb (m5.3). We present here the sequence analysis of m1.7 and its putative product, rnprot1.7, and show that rnprot1.7 is similar to the product of the human n-chimaerin gene, which is expressed in brain and testes. Recently, the GAP activity of n-chimaerin was demonstrated and shown to be specific for the Rac subfamily of the Ras oncoproteins. The Rac proteins have been implicated in the regulation of secretory processes. In addition to being expressed in the imaginal discs, the m1.7 racGAP transcript was detected in developmentally specific germ line cells of the testes, the primary spermatocytes.

机译：果蝇的果蝇（rn）位点位于细胞遗传学位置84D3,4，并已根据突变表型进行了克隆：在附肢的近端区域不存在结构。附肢的缩短是成年附肢的前体假想椎间盘中局部细胞死亡的结果。 rn位点的物理特征表明它相对较大，至少占据50 kb。有1.7 kb（m1.7）和5.3 kb（m5.3）的两个主要转录本。我们在这里介绍了m1.7及其推定产物rnprot1.7的序列分析，并显示rnprot1.7与人n-chimaerin基因的产物相似，后者在大脑和睾丸中表达。最近，证明了n-chimaerin的GAP活性，并显示出它对Ras癌蛋白的Rac亚家族具有特异性。 Rac蛋白与分泌过程的调节有关。除了在假想椎间盘中表达外，还在睾丸的发育特异性生殖系细胞即原代精子细胞中检测到了m1.7 racGAP转录本。

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期刊名称 Molecular and Cellular Biology
作者
M Agnel; L Röder; C Vola; R Griffin-Shea;
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作者单位

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年(卷),期 1992(12),11
年度 1992
页码 5111–5122
总页数 12
原文格式 PDF
正文语种
中图分类分子生物学;细胞生物学;
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1. A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins. [J] . M Agnel, L R?der, C Vola, Molecular and Cellular Biology . 1992,第11期

机译：在精子发生和假想椎间盘形态发生过程中表达的果蝇圆形体转录物编码的蛋白质类似于人Rac GTPase激活（racGAP）蛋白质。
2. Control of Drosophila imaginal disc development by rotund and roughened eye: differentially expressed transcripts of the same gene encoding functionally distinct zinc finger proteins. [J] . St-Pierre SusanE, Galindo MaximoI, Couso JuanP, Development . 2002,第5期

机译：果蝇和粗糙眼睛控制果蝇假体盘的发育：同一基因的差异表达转录本，其编码功能不同的锌指蛋白。
3. Genes expressed during imaginal discs morphogenesis: IMP-L2, a gene expressed during imaginal disc and imaginal histoblast morphogenesis☆ [J] . David L. Osterbur, Dianne K. Fristrom, Jeanette E. Natzle, Developmental biology . 1988,第2期

机译：椎间盘形态发生过程中表达的基因：IMP-L2，椎间盘形态和组织成象过程中表达的基因☆
4. Binary Pattern Dictionary Learning for Gene Expression Representation in Drosophila Imaginal Discs [C] . Jiri Borovec, Jan Kybic Asian conference on computer vision . 2017

机译：二进制图案字典学习果蝇的基因表达式表示
5. Studies on the characterization and expression of the genes encoding the rat glutamine/glutamic acid-rich proteins. [D] . Bermudez, Francisco Luis. 1998

机译：研究编码大鼠谷氨酰胺/谷氨酸丰富蛋白的基因的特征和表达。
6. Ectopic Expression of DREF Induces DNA Synthesis Apoptosis and Unusual Morphogenesis in the Drosophila Eye Imaginal Disc: Possible Interaction with Polycomb and trithorax Group Proteins [O] . Fumiko Hirose, Nobuko Ohshima, Michina Shiraki, 2001

机译：DREF的异位表达诱导果蝇眼想象盘中的DNA合成细胞凋亡和异常形态发生：可能与Polycomb和trithorax组蛋白相互作用。
7. A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins. [O] . Agnel, M, Röder, L, Vola, C, 1992

机译：在精子发生和假想椎间盘形态发生过程中表达的果蝇圆形体转录物编码的蛋白质类似于人Rac GTPase激活（racGAP）蛋白质。
8. Nucleotide Sequence of the Hantaan Virus S RNA Segment and Expression of Encoded Proteins. [R] . Jennings, G. B. 1987

机译：汉滩病毒s RNa片段的核苷酸序列和编码蛋白的表达。

A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins.

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