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Malondialdehyde Glutathione and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients

机译:弓形虫血清反应阳性患者的丙二醛谷胱甘肽和一氧化氮水平

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摘要

The aim of this study was to investigate the difference in the serum malondialdehyde (MDA), glutathione (GSH), and nitric oxide (NO) levels between normal and T. gondii-infected patients. To this end, MDA, GSH, and NO levels in the sera of 37 seropositive patients and 40 participants in the control group were evaluated. In Toxoplasma ELISA, IgG results of the patient group were 1,013.0 ± 543.8 in optical density (mean ± SD). A statistically significant difference was found between patients and the control group in terms of MDA, GSH, and NO levels. A decrease in GSH activity was detected, while MDA and NO levels increased significantly. Consequently, it is suggested that the use of antioxidant vitamins in addition to a parasite treatment shall prove useful. The high infection vs control ratio of MDA and NO levels probably suggests the occurrence as a mechanism of tissue damage in cases of chronic toxoplasmosis. Moreover, it is recommended that the patient levels of MDA, GSH, and NO should be evaluated in toxoplasmosis.
机译:这项研究的目的是调查正常和弓形虫感染患者之间的血清丙二醛(MDA),谷胱甘肽(GSH)和一氧化氮(NO)水平的差异。为此,对37名血清阳性患者和对照组的40名参与者的血清中的MDA,GSH和NO水平进行了评估。在弓形虫ELISA中,患者组的IgG结果的光密度为1,013.0±543.8(平均值±SD)。在患者和对照组之间,MDA,GSH和NO水平存在统计学差异。检测到GSH活性降低,而MDA和NO水平显着增加。因此,建议除寄生虫治疗外还应使用抗氧化剂维生素。 MDA和NO水平的高感染率与控制率之比很可能表明在慢性弓形体病病例中,这是组织损伤的一种机制。此外,建议应评估弓形虫病患者的MDA,GSH和NO水平。

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