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The changing microbial landscape of Western society: Diet dwellings and discordance

机译:西方社会不断变化的微生物格局:饮食住所和不和谐

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摘要

BackgroundThe last 50–100 years has been marked by a sharp rise in so-called “Western-diseases” in those countries that have experienced major industrial advances and shifts towards urbanized living. These diseases include obesity, type 2 diabetes, inflammatory bowel diseases, and food allergies in which chronic dysregulation of metabolic and/or immune processes appear to be involved, and are likely a byproduct of new environmental influences on our ancient genome. What we now appreciate is that this genome consists of both human and co-evolved microbial genes of the trillions of microbes residing in our body. Together, host–microbe interactions may be determined by the changing diets and behaviors of the Western lifestyle, influencing the etiopathogenesis of “new-age” diseases.
机译:背景信息在过去的50–100年中,那些经历了重大工业进步并朝着城市化生活转变的国家中所谓的“西方疾病”急剧增加。这些疾病包括肥胖,2型糖尿病,炎症性肠病和食物过敏,其中涉及代谢和/或免疫过程的慢性失调,并且很可能是新环境影响我们古代基因组的副产品。我们现在欣赏的是,该基因组由人类和共同进化的微生物基因组成,它们存在于我们体内的数万亿个微生物中。总之,宿主与微生物之间的相互作用可能取决于西方生活方式的饮食和行为的变化,从而影响“新时代”疾病的病因。

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