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Synthesis Characterization and Biological Activities of Cu(II) Co(II) Mn(II) Fe(II) and UO2(VI) Complexes with a New Schiff Base Hydrazone: O-Hydroxyacetophenone-7-chloro-4-quinoline Hydrazone

机译：具有新型席夫碱Hy的Cu（II）Co（II）Mn（II）Fe（II）和UO2（VI）配合物的合成表征和生物活性：O-羟基乙酰苯酮-7-chloro-4-喹Hy Hy

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The Schiff base hydrazone ligand >HL was prepared by the condensation reaction of 7-chloro-4-quinoline with o-hydroxyacetophenone. The ligand behaves either as monobasic bidentate or dibasic tridentate and contain ONN coordination sites. This was accounted for be the presence in the ligand of a phenolic azomethine and imine groups. It reacts with Cu(II), Ni(II), Co(II), Mn(II), UO2 (VI) and Fe(II) to form either mono- or binuclear complexes. The ligand and its metal complexes were characterized by elemental analyses, IR, NMR, Mass, and UV-Visible spectra. The magnetic moments and electrical conductance of the complexes were also determined. The Co(II), Ni(II) and UO2 (VI) complexes are mononuclear and coordinated to NO sites of two ligand molecules. The Cu(II) complex has a square-planar geometry distorted towards tetrahedral, the Ni(II) complex is octahedral while the UO2 (VI) complex has its favoured heptacoordination. The Co(II), Mn(II) complexes and also other Ni(II) and Fe(III) complexes, which were obtained in the presence of Li(OH) as deprotonating agent, are binuclear and coordinated via the NNNO sites of two ligand molecules. All the binuclear complexes have octahedral geometries and their magnetic moments are quite low compared to the calculated value for two metal ions complexes and thus antiferromagnetic interactions between the two adjacent metal ions. The ligand >HL and metal complexes were tested against a strain of Gram +ve bacteria (Staphylococcus aureus), Gram −ve bacteria (Escherichia coli), and fungi (Candida albicans). The tested compounds exhibited high antibacterial activities.

机译：通过7-氯-4-喹啉与邻羟基苯乙酮的缩合反应制备席夫碱配体> HL 。配体表现为一元二齿或二元三齿，并包含ONN配位点。这是由于在配体中存在苯酚甲亚甲亚胺和亚胺基。它与Cu（II），Ni（II），Co（II），Mn（II），UO2（VI）和Fe（II）反应形成单核或双核络合物。配体及其金属络合物通过元素分析，IR，NMR，质量和UV-可见光谱进行表征。还确定了配合物的磁矩和电导率。 Co（II），Ni（II）和UO2（VI）络合物是单核的，并与两个配体分子的NO位点配位。 Cu（II）络合物具有向四面体变形的正方形平面几何形状，Ni（II）络合物为八面体，而UO2（VI）络合物则具有七面体配位。 Co（II），Mn（II）配合物以及其他Ni（II）和Fe（III）配合物是在Li（OH）作为去质子化剂的条件下获得的，是双核的，并且通过两个NNNO位点进行配位配体分子。所有的双核络合物都具有八面体的几何形状，并且与两个金属离子络合物的计算值相比，其磁矩非常低，因此与两个相邻金属离子之间的反铁磁相互作用有关。测试了配体> HL 和金属配合物对革兰氏+ ve细菌（金黄色葡萄球菌），革兰氏ve细菌（大肠埃希氏菌）和真菌（白色念珠菌）的作用。被测化合物表现出高抗菌活性。

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期刊名称 Molecules
作者
Nora H. Al-Shaalan;
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作者单位

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年(卷),期 2011(16),10
年度 2011
页码 8629–8645
总页数 17
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
Schiff base ligand metal complexes antimicrobial IR spectra UV-Vis spectra;

机译：席夫碱配体;金属络合物;抗菌剂;红外光谱;紫外-可见光谱;

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1. Synthesis, Characterization and Biological Activities of Cu(II), Co(II), Mn(II), Fe(II), and UO2(VI) Complexes with a New Schiff Base Hydrazone: O-Hydroxyacetophenone-7-chloro-4-quinoline Hydrazone [J] . Nora H. Al-Shaalan Molecules . 2011,第10期

机译：具有新型席夫碱Hy的Cu（II），Co（II），Mn（II），Fe（II）和UO2（VI）配合物的合成，表征和生物活性：O-羟基乙酰苯酮-7-chloro-4-喹啉Hy
2. Synthesis and Characterization of Cr(III), Mn(III), Fe(III), VO(IV), Zr(IV) and UO2(VI) Complexes of Schiff Base Derived from Isonicotinoyl Hydrazone [J] . Gawande Pranita U., Mandlik P. R., Aswar A. S. Indian journal of pharmaceutical sciences. . 2015,第4期

机译：异烟酰胺基Hy席夫碱的Cr（III），Mn（III），Fe（III），VO（IV），Zr（IV）和UO2（VI）配合物的合成与表征
3. Synthesis, Characterization and Biological Activities of Cu(II), Co(II), Ni(II), Mn(II) and Fe(III) Complexes with Schiff Base Derived from 3-(4-Chlorophenoxymethyl)-4-amino-5-mercapto-1,2,4-triazole [J] . VidyavatiReddy, NirdoshPatil, TukaramReddy, Journal of Chemistry . 2008,第3期

机译：Cu（II），Co（II），Ni（II），Ni（II），Mn（II）和Fe（III）复合物的合成，表征和生物活性与Schiff碱衍生自3-（4-氯苯甲氧基甲基）-4-氨基-5 -mercapto-1,2,4-三唑
4. Synthesis, Characterization and Biological Activity Evaluation of Novel Pd(II) and Pt(II) Complexes with Heterocyclic Hydrazone Ligands [C] . N. R. Filipovic, T. R. Todorovic, D. M. Sladic, Yugoslav Materials Restarch Society Conference . 2007

机译：用杂环腙配体的新型Pd（II）和Pt（II）配合物的合成，表征和生物活性评价
5. The structure and reactivity of a series of high-valent oxo complexes of Ru and Mn: Ru(III)-mediated catalytic oxygenation of triphenylphosphine, characterization of binuclear Mn(III,III) and Mn(III,IV) dimers, and mononuclear iron(III) and iron(IV). [D] . Fackler, Nathanael L. P. 1997

机译：Ru和Mn的一系列高价羰基配合物的结构和反应性：Ru（III）介导的三苯膦催化氧化，双核Mn（III，III）和Mn（III，IV）二聚体的表征以及单核铁（III）和铁（IV）。
6. Synthesis characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone [O] . Jing Xie, Shanshan Shen, Ruhua Chen, -1

机译：n-席夫碱衍生自2-乙酰吡啶和异烟肼ino的Ln（III）配合物的合成表征和抗肿瘤活性
7. Synthesis, Characterization and Biological Activities of Cu(II), Co(II), Mn(II), Fe(II), and UO2(VI) Complexes with a New Schiff Base Hydrazone: O-Hydroxyacetophenone-7-chloro-4-quinoline Hydrazone [O] . Nora H. Al-Shaalan 2011

机译：具有新型席夫碱Hy的Cu（II），Co（II），Mn（II），Fe（II）和UO2（VI）配合物的合成，表征和生物活性：O-羟基乙酰苯-7-chloro-4-喹Hy Hy

Synthesis Characterization and Biological Activities of Cu(II) Co(II) Mn(II) Fe(II) and UO2(VI) Complexes with a New Schiff Base Hydrazone: O-Hydroxyacetophenone-7-chloro-4-quinoline Hydrazone

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