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首页> 美国卫生研究院文献>Molecules >Metabolomic Analysis of Two Parmotrema Lichens: P. robustum (Degel.) Hale and P. andinum (Mull. Arg.) Hale Using UHPLC-ESI-OT-MS-MS
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Metabolomic Analysis of Two Parmotrema Lichens: P. robustum (Degel.) Hale and P. andinum (Mull. Arg.) Hale Using UHPLC-ESI-OT-MS-MS

机译：使用UHPLC-ESI-OT-MS-MS对两种腮腺扁平苔藓：强壮假单胞菌（Degel。）Hale和P. andinum（Mull。Arg。）Hale进行代谢组学分析

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摘要

Lichens are symbiotic associations of fungi with microalgae and/or cyanobacteria. Lichens belonging to the Parmeliaceae family comprise 2700 species of lichens, including the Parmotrema genus which is composed of 300 species. The metabolites of this genus include depsides, depsidones, phenolics, polysaccharides, lipids, diphenylethers and dibenzofurans, which are responsible for the biological activities reported including antidiabetic, antihelmintic, anticancer, antioxidant, antibacterial, anti-inflammatory, antimitotic, antitumoral, antifungal, and antioxidant enzyme inhibitory. Due to scarce knowledge of metabolomic profiles of Parmotrema species (P. andinum and P. robustum), a full metabolome study based on ultra-high performance liquid chromatography- diode array detector-electrospray ionization-quadrupole-orbitrap-mass-spectrometry (UHPLC-DAD-ESI-Q-orbitrap MS) was performed for a comprehensive characterization of their substances. From the methanolic extracts of these species, a total of 54 metabolites were identified for the first time using this hyphenated technique, including thirty compounds in P. andinum, and thirty-seven in P. robustum. Moreover, two compounds were not identified as known compounds, and could be new structures, according to our data. This report shows that this technique is effective and accurate for rapid chemical identification of lichen substances and the compounds identified could serve as chemotaxonomic markers to differentiate these ruffle lichens.
机译：地衣是真菌与微藻和/或蓝细菌的共生联系。属于伞形科的地衣包括2700种地衣，包括由300种组成的Parmotrema属。该属的代谢产物包括去垢剂，地烯二酚，酚类，多糖，脂质，二苯醚和二苯并呋喃，它们负责报道的生物活性，包括抗糖尿病，抗蠕虫，抗癌，抗氧化剂，抗菌，抗炎，抗有丝分裂，抗肿瘤，抗真菌和抗氧化酶抑制作用。由于对帕莫氏菌属物种（P. andinum和P.robustum）的代谢组学资料了解不足，因此，基于超高效液相色谱-二极管阵列检测器-电喷雾电离-四极杆-轨道阱-质谱（UHPLC-进行了DAD-ESI-Q-orbitrap MS）的全面表征。使用这种联用技术，首次从这些物种的甲醇提取物中鉴定出总共54种代谢物，包括P. andinum中的30种化合物和P.robustum中的37种化合物。此外，根据我们的数据，尚未鉴定出两种化合物为已知化合物，并且可能是新结构。该报告表明，该技术对于快速化学鉴定地衣物质是有效且准确的，所鉴定的化合物可以用作区分这些皱纹地衣的化学分类标记。

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