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Akanthopyrones A–D α-Pyrones Bearing a 4-O-Methyl-β-d-glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis

机译：来自蜘蛛相关子囊虫Akanthomyces novoguineensis的带有4-O-甲基-β-d-吡喃葡萄糖部分的Akanthopyrones A–Dα-吡喃酮

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Hypocrealean fungi have proved to be prolific bioactive metabolite producers; they have caught the attention of mycologists throughout the world. However, only a few studies on the insect and spider parasitic genus Akanthomyces have so far been carried out. In this study, we report the isolation, structural elucidation and biological activities of four unprecedented glycosylated α-pyrone derivatives, akanthopyrones A–D (>1–>4), from a culture of Akanthomyces novoguineensis collected in Thailand. The chemical structures of the akanthopyrones were determined by extensive 1D- and 2D-NMR, and HRMS spectroscopic analysis. Their absolute configurations were determined. Akanthopyrone A (>1) exhibited weak antimicrobial activity against Bacillus subtilis DSM10 and cytotoxicity against the HeLa cell line KB-3-1, while akanthopyrone D (>4) showed weak activity against Candida tenuis MUCL 29892.

机译：业已证明次胰真菌是生物活性代谢产物的多产者。它们引起了全世界真菌学家的关注。但是，到目前为止，仅对昆虫和蜘蛛寄生的Akanthomyces进行了很少的研究。在这项研究中，我们报告了一种文化中四种史无前例的糖基化α-吡喃酮衍生物-kan啶酮A–D（> 1 – > 4 ）的分离，结构解析和生物学活性。泰国采集的Akanthomyces novoguineensis。通过广泛的1D-NMR和2D-NMR以及HRMS光谱分析确定了千金酮的化学结构。确定了它们的绝对构型。 Akanthopyrone A（> 1 ）表现出对枯草芽孢杆菌DSM10弱的抗菌活性和对HeLa细胞系KB-3-1的细胞毒性，而Akanthopyrone D（> 4 ）表现出的抗弱活性念珠菌MUCL 29892。

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期刊名称 Molecules
作者
Wilawan Kuephadungphan; Soleiman E. Helaly; Charuwan Daengrot; Souwalak Phongpaichit; Janet Jennifer Luangsa-ard; Vatcharin Rukachaisirikul; Marc Stadler;
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作者单位

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年(卷),期 2017(22),7
年度 2017
页码 1202
总页数 10
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
cordycipitaceae hypocreales invertebrate-associated fungi α-pyrones 4-O-methyl-β-d-glucopyranose;

机译：虫草科;降尿菌;无脊椎动物相关真菌;α-吡喃酮;4-O-甲基-β-d-吡喃葡萄糖;

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1. Akanthopyrones A–D, α-Pyrones Bearing a 4-O-Methyl-β-d-glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis [J] . Wilawan Kuephadungphan, Soleiman Helaly, Charuwan Daengrot, Molecules . 2017,第7期

机译：蜘蛛相关的子囊Akanthomyces novoguineensis带有4-O-甲基-β-d-吡喃葡萄糖部分的Akanthopyrones A–D，α-吡喃酮
2. Akanthopyrones A–D, α-Pyrones Bearing a 4- O -Methyl-β- d -glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis [J] . Wilawan Kuephadungphan, Soleiman E. Helaly, Charuwan Daengrot, Molecules . 2017,第7期

机译：蜘蛛相关子囊Akanthomyces novoguineensis带有4-O-甲基-β-d-吡喃葡萄糖部分的Akanthopyrones A–D，α-吡喃酮
3. Akanthopyrones A-D, α-Pyrones Bearing a 4-O-Methyl-β-d-glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis. [O] . Kuephadungphan Wilawan, Helaly Soleiman E, Daengrot Charuwan, 2017

机译：来自与蜘蛛相关的子囊夜蛾Akanthomyces novoguineensis的带有4-O-甲基-β-d-吡喃葡萄糖部分的Akanthopyrones A-D，α-Pyrones。

Akanthopyrones A–D α-Pyrones Bearing a 4-O-Methyl-β-d-glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis

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