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首页> 美国卫生研究院文献>Molecules >10-HDA A Major Fatty Acid of Royal Jelly Exhibits pH Dependent Growth-Inhibitory Activity Against Different Strains of Paenibacillus larvae
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10-HDA A Major Fatty Acid of Royal Jelly Exhibits pH Dependent Growth-Inhibitory Activity Against Different Strains of Paenibacillus larvae

机译：10-HDA蜂王浆的主要脂肪酸对不同菌株的杆状芽孢杆菌幼虫具有pH依赖性的生长抑制活性。

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Paenibacillus larvae (P. larvae) is a bacterial pathogen causing American foulbrood (AFB), the most serious disease of honeybee larvae. The food of young larvae could play an important role in the resistance of larvae against AFB. It contains antibacterial substances produced by honeybees that may inhibit the propagation of the pathogen in larval midguts. In this study, we identified and investigated the antibacterial effects of one of these substances, trans-10-hydroxy-2-decenoic acid (10-HDA), against P. larvae strains including all Enterobacterial Repetitive Intergenic Consensus (ERIC) genotypes. Its inhibitory activities were studied by determining the minimum inhibitory concentrations (MICs). It was found that 10-HDA efficacy increases substantially with decreasing pH; up to 12-fold differences in efficacy were observed between pH = 5.5 and pH = 7.2. P. larvae strains showed different susceptibility to 10-HDA; up to 2.97-fold differences existed among various strains with environmentally important ERIC I and ERIC II genotypes. Germinating spores of the pathogen were generally more susceptible to 10-HDA than vegetative cells. Our findings suggest that 10-HDA could play significant role in conferring antipathogenic activity to larval food in the midguts of young larvae and contribute to the resistance of individual larvae to P. larvae.
机译：幼虫Paenibacillus幼虫（P.幼虫）是引起美国臭蝇（AFB）的细菌病原体，AFB是蜜蜂幼虫最严重的疾病。幼虫的食物可能在幼虫对AFB的抗性中起重要作用。它包含蜜蜂产生的抗菌物质，它们可能会抑制病原体在幼虫中肠中的繁殖。在这项研究中，我们确定并研究了其中一种物质反式-10-羟基-2-癸烯酸（10-HDA）对P.幼虫菌株的抗菌作用，其中包括所有肠道细菌重复性基因间共识（ERIC）基因型。通过确定最小抑菌浓度（MIC）研究了其抑菌活性。发现10-HDA的功效随着pH的降低而显着增加。在pH = 5.5和pH = 7.2之间，观察到功效差异高达12倍。 P.幼虫菌株对10-HDA的敏感性不同。在具有重要环境意义的ERIC I和ERIC II基因型的不同菌株之间存在高达2.97倍的差异。与营养细胞相比，病原体的萌芽孢子通常对10-HDA更敏感。我们的研究结果表明10-HDA可以在赋予幼虫中肠幼虫食物抗病活性方面发挥重要作用，并有助于单个幼虫对P.幼虫的抗性。

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