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首页> 美国卫生研究院文献>Molecules >The Effect of Tartary Buckwheat Flavonoids in Inhibiting the Proliferation of MGC80-3 Cells during Seed Germination
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The Effect of Tartary Buckwheat Flavonoids in Inhibiting the Proliferation of MGC80-3 Cells during Seed Germination

机译：苦荞中黄酮类化合物抑制种子萌发过程中MGC80-3细胞增殖的作用

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摘要

Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn) is rich in functional compounds such as rutin, quercetin, d-chiro-inositol, dietary fiber, and essential amino acids. Electric field (EF) treatment before sprout germination results in physiological and chemical changes, and some alterations might lead to positive applications in plant seeds. MTT assay showed that the effect of total flavonoids on human gastric cancer cell line MGC80-3 was significantly changed after EF treatment for different germination days (3–7 days). Among them, the total flavonoids of tartary buckwheat (BWTF) on the third day had the most obvious inhibitory effect on MGC80-3 (p < 0.01). In addition, flow cytometry evidenced that different ratios of quercetin and rutin had effects on the proliferation of MGC80-3. The same content of quercetin and rutin had the best effect, reaching 6.18 ± 0.82%. The anti-cancer mechanism was mainly promoted by promoting the expression of apoptotic proteins. The expression of Bax/Bcl-2 and caspase-8 in MGC80-3 cells was mediated by BWTFs. This study has good research value for improving the biological and economic value of tartary buckwheat.
机译：苦荞（Fagopyrum tataricum（L.）Gaertn）富含功能化合物，如芦丁，槲皮素，d-手性肌醇，膳食纤维和必需氨基酸。发芽前的电场处理导致生理和化学变化，某些变化可能导致植物种子获得积极的应用。 MTT分析表明，在不同发芽天数（3-7天）进行EF处理后，总黄酮对人胃癌细胞系MGC80-3的影响发生了显着变化。其中，第3天的苦荞总黄酮对MGC80-3的抑制作用最明显（p <0.01）。另外，流式细胞术证明槲皮素和芦丁的不同比例对MGC80-3的增殖有影响。槲皮素和芦丁含量相同时效果最好，达到6.18±0.82％。抗癌机制主要是通过促进凋亡蛋白的表达来促进的。 BWTFs介导了MGC80-3细胞中Bax / Bcl-2和caspase-8的表达。该研究对于改善苦荞的生物学和经济价值具有很好的研究价值。

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