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首页> 美国卫生研究院文献>Molecules >Contribution of Secondary Metabolites to the Gastroprotective Effect of Aqueous Extract of Ximenia americana L. (Olacaceae) Stem Bark in Rats
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Contribution of Secondary Metabolites to the Gastroprotective Effect of Aqueous Extract of Ximenia americana L. (Olacaceae) Stem Bark in Rats

机译：次生代谢产物对美洲剑麻茎皮水提取物胃保护作用的影响

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Ximenia americana L. (Olacaceae) is used in ethnomedicine as cicatrizant and for the treatment of gastric disorders. This study identified the chemical constituents of the aqueous extract of X. americana (XaAE) and evaluated its antiulcerogenic activity. After lyophilization, XaAE was analyzed by liquid chromatography-mass spectrometry (LC-MS) and its antiulcerogenic effect was evaluated in acute gastric lesions induced by ethanol, acidified ethanol, and indomethacin. Antisecretory action, mucus production and the participation of sulfhydryl groups (–SH) and nitric oxide (NO) were also investigated. The chromatographic analysis identified procyanidins B and C and catechin/epicatechin as major compounds. Oral administration of XaAE (100, 200 and 400 mg/kg) inhibited the gastric lesions induced by ethanol (76.1%, 77.5% and 100%, respectively), acidified ethanol (44.9%, 80.6% and 94.9%, respectively) and indomethacin (56.4%, 52.7% and 64.9%, respectively). XaAE reduced gastric contents and acidity (51.4% and 67.7%, respectively) but did not alter the production of gastric mucus. The reduction of the -SH and NO groups promoted by N-ethylmaleimide (NEM) and Nω-nitro-l-arginine-methyl-ester (L-NAME) respectively, reduced the gastroprotective effect of XaAE. In conclusion, XaAE has gastroprotective activity mediated in part by -SH, NO and antisecretory activity. This antiulcer action was initially correlated to its major constituents, procyanidins B and C and catechin/epicatechin.
机译：Ximenia americana L.（Olacaceae）在乙炔诺地卡因中用作抗癌药和治疗胃部疾病。这项研究确定了美洲X.AE（XaAE）水提取物的化学成分，并评估了其抗溃疡活性。冻干后，通过液相色谱-质谱（LC-MS）分析XaAE，并评估其在乙醇，酸化乙醇和消炎痛引起的急性胃部病变中的抗溃疡作用。还研究了抗分泌作用，粘液产生以及巯基（–SH）和一氧化氮（NO）的参与。色谱分析确定原花青素B和C和儿茶素/表儿茶素为主要化合物。口服XaAE（100、200和400 mg / kg）可抑制乙醇（分别为76.1％，77.5％和100％），酸化乙醇（分别为44.9％，80.6％和94.9％）和消炎痛诱导的胃部病变（分别为56.4％，52.7％和64.9％）。 XaAE降低了胃内容物和酸度（分别为51.4％和67.7％），但没有改变胃粘液的产生。 N-乙基马来酰亚胺（NEM）和Nω-硝基-1-精氨酸甲基酯（L-NAME）分别促进了-SH和NO的还原，降低了XaAE的胃保护作用。总之，XaAE具有部分由-SH，NO和抗分泌活性介导的胃保护活性。这种抗溃疡作用最初与它的主要成分，原花青素B和C和儿茶素/表儿茶素有关。

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