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首页> 美国卫生研究院文献>Molecules >Extraction Purification Structural Characteristics Biological Activities and Pharmacological Applications of Acemannan a Polysaccharide from Aloe vera: A Review
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Extraction Purification Structural Characteristics Biological Activities and Pharmacological Applications of Acemannan a Polysaccharide from Aloe vera: A Review

机译：芦荟多糖Acemannan的提取纯化结构特征生物学活性和药理应用研究进展

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摘要

Aloe vera is a medicinal plant species of the genus Aloe with a long history of usage around the world. Acemannan, considered one of the main bioactive polysaccharides of Aloe vera, possesses immunoregulation, anti-cancer, anti-oxidation, wound healing and bone proliferation promotion, neuroprotection, and intestinal health promotion activities, among others. In this review, recent advancements in the extraction, purification, structural characteristics and biological activities of acemannan from Aloe vera were summarized. Among these advancements, the structural characteristics of purified polysaccharides were reviewed in detail. Meanwhile, the biological activities of acemannan from Aloe vera determined by in vivo, in vitro and clinical experiments are summarized, and possible mechanisms of these bioactivities were discussed. Moreover, the latest research progress on the use of acemannan in dentistry and wound healing was also summarized in details. The structure-activity relationships of acemannan and its medical applications were discussed. Finally, new perspectives for future research work on acemannan were proposed. In conclusion, this review summarizes the extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan, and provides information for the industrial production and possible applications in dentistry and wound healing in the future.
机译：芦荟是芦荟属的药用植物，在世界范围内有悠久的使用历史。阿魏甘露聚糖被认为是芦荟的主要生物活性多糖之一，具有免疫调节，抗癌，抗氧化，促进伤口愈合和促进骨增殖，神经保护以及促进肠道健康等作用。本文综述了芦荟中乙酰甘露聚糖的提取，纯化，结构特征和生物学活性的最新进展。在这些进展中，详细综述了纯化多糖的结构特征。同时，总结了通过体内，体外和临床实验确定的芦荟醋甘露聚糖的生物活性，并探讨了这些生物活性的可能机理。此外，还详细总结了在牙科和伤口愈合中使用乙酰甘露聚糖的最新研究进展。讨论了乙酰甘露聚糖的构效关系及其医学应用。最后，提出了有关醋曼聚糖未来研究工作的新观点。总之，本综述总结了乙酰甘露聚糖的提取，纯化，结构特征，生物学活性和药理应用，并为工业生产以及将来在牙科和伤口愈合中的可能应用提供信息。

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