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首页> 美国卫生研究院文献>Molecules >Carbon and Tin-Based Polyacrylonitrile Hybrid Architecture Solid Phase Microextraction Fiber for the Detection and Quantification of Antibiotic Compounds in Aqueous Environmental Systems
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Carbon and Tin-Based Polyacrylonitrile Hybrid Architecture Solid Phase Microextraction Fiber for the Detection and Quantification of Antibiotic Compounds in Aqueous Environmental Systems

机译：碳和锡基聚丙烯腈混合结构固相微萃取纤维用于检测和定量水环境系统中的抗生素化合物

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摘要

In this study, the detection and quantification of multiple classes of antibiotics in water matrices are proposed using a lab-made solid phase microextraction (SPME) fiber coupled with high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The lab-made fiber was prepared using a graphene oxide (G), carbon nanotubes (C), and tin dioxide (T) composite, namely GCT, with polyacrylonitrile (PAN) as supporting material. The detected antibiotics were enrofloxacin, sulfathiazole, erythromycin, and trimethoprim. The custom-made fiber was found to be superior compared with a commercial C18 fiber. The excellent reproducibility and lower intra-fiber relative standard deviations (RSDs 1.8% to 6.8%) and inter-fiber RSDs (4.5% to 8.8%) made it an ideal candidate for the detection of traces of antibiotics in real environmental samples. The proposed validated method provides a satisfactory limit of detection and good linear ranges with higher (>0.99) coefficient of determination in the aqueous system. Application of the method was made in different real water systems such as river, pond and tap water using the standard spiking method. Excellent sensitivity, reproducibility, lower amount of sample detection and higher recovery was found in a real water sample. Therefore, the extraction method was successfully applied to the detection and quantification of multiple classes of antibiotics in different aqueous systems with satisfactory results.
机译：在这项研究中，提出了一种使用实验室制造的固相微萃取（SPME）纤维与高效液相色谱-串联质谱（LC-MS / MS）结合对水基质中多种抗生素进行检测和定量的方法。实验室制造的纤维是使用氧化石墨烯（G），碳纳米管（C）和二氧化锡（T）复合材料（即GCT）制成的，其中聚丙烯腈（PAN）为支撑材料。检出的抗生素为恩诺沙星，磺胺噻唑，红霉素和甲氧苄啶。发现定制纤维比市售C18纤维优越。出色的重现性和较低的纤维内相对标准偏差（RSD为1.8％至6.8％）和纤维间RSD（4.5％至8.8％）使其成为检测实际环境样品中痕量抗生素的理想候选物。所提出的经过验证的方法提供了令人满意的检测限和良好的线性范围，并在水性体系中具有更高的（> 0.99）测定系数。使用标准加标方法将该方法应用于不同的实际水系统，例如河流，池塘和自来水。在真实的水样中发现了极好的灵敏度，可重复性，更少的样品检测量和更高的回收率。因此，该提取方法已成功应用于不同水系统中多种抗生素的检测和定量，结果令人满意。

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