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首页> 美国卫生研究院文献>Molecules >Anti-Inflammatory Effects of High Hydrostatic Pressure Extract of Mulberry (Morus alba) Fruit on LPS-Stimulated RAW264.7 Cells
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Anti-Inflammatory Effects of High Hydrostatic Pressure Extract of Mulberry (Morus alba) Fruit on LPS-Stimulated RAW264.7 Cells

机译：桑果高静水压提取物对LPS刺激的RAW264.7细胞的抗炎作用

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摘要

Mulberry fruit (Morus alba L.) contains abundant bioactive compounds, including anthocyanins and flavonols, and has been reported to possess potent beneficial properties including anticancer, antidiabetic, and anti-oxidant effects. High hydrostatic pressure (HHP) processing, a nonthermal food processing technology, is suitable for the extraction of bioactive compounds from plants. Nevertheless, the anti-inflammatory effects of HHP extract of mulberry fruit (HM) in RAW264.7 cells remain unclear. The present study aimed to investigate the anti-inflammatory effects of HM on lipopolysaccharide (LPS)-induced inflammation in vitro. RAW264.7 cells were treated with various concentrations (0.1–1 μg/mL) of HM in the presence or absence of LPS. HM inhibited the inflammatory mediator, nitric oxide (NO) release, and mRNA expression of nitric oxide synthase 2 (NOS2) in LPS-induced RAW264.7 cells. In addition, HM suppressed both mRNA and protein expressions of prostaglandin-endoperoxide synthase 2 (PTGS2). Moreover, it reduced the LPS-induced secretion of proinflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α. These results revealed that HM exerts anti-inflammatory effects by inhibiting several mediators and cytokines involved in the inflammatory process.
机译：桑果（Morus alba L.）含有丰富的生物活性化合物，包括花青素和黄酮醇，据报道具有有效的有益特性，包括抗癌，抗糖尿病和抗氧化作用。高静水压（HHP）处理是一种非热食品处理技术，适用于从植物中提取生物活性化合物。尽管如此，桑树果实HHP提取物（HM）在RAW264.7细胞中的抗炎作用仍不清楚。本研究旨在研究HM对脂多糖（LPS）诱导的体外炎症的抗炎作用。在存在或不存在LPS的情况下，用各种浓度（0.1–1μg/ mL）的HM处理RAW264.7细胞。 HM抑制LPS诱导的RAW264.7细胞中的炎性介质，一氧化氮（NO）释放和一氧化氮合酶2（NOS2）的mRNA表达。此外，HM抑制前列腺素内过氧化物合酶2（PTGS2）的mRNA和蛋白质表达。此外，它减少了LPS诱导的促炎细胞因子如白介素（IL）-6和肿瘤坏死因子（TNF）-α的分泌。这些结果表明，HM通过抑制炎症过程中涉及的几种介质和细胞因子发挥抗炎作用。

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