Influence of Previous Statin Therapy on Cholesterol-Lowering Effect of Ezetimibe

机译：以前的他汀类药物治疗对依泽替米贝降低胆固醇的影响

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摘要

Background and ObjectivesThe inhibition of cholesterol absorption by ezetimibe increases cholesterol synthesis. The effect of inhibition of cholesterol synthesis on cholesterol absorption is controversial. The influence of these interactions on cholesterol levels is unknown. We investigated on the extent to which cholesterol levels were affected by the reaction of one pathway to the inhibition of the other pathway.

机译：背景与目的依泽替米贝抑制胆固醇的吸收可增加胆固醇的合成。抑制胆固醇合成对胆固醇吸收的作用是有争议的。这些相互作用对胆固醇水平的影响尚不清楚。我们调查了一种途径对另一种途径的抑制作用对胆固醇水平的影响程度。

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期刊名称 Korean Circulation Journal
作者
Young Hwan Choi; Young Kim; Cheol Won Hyeon; Seonghyup Hyun; Jee Eun Kwon; Hoyoun Won; Seung Yong Shin; Wang-Soo Lee; Kwang Je Lee; Sang-Wook Kim; Tae Ho Kim; Chee Jeong Kim;
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年(卷),期 2014(44),4
年度 2014
页码 227–232
总页数 6
原文格式 PDF
正文语种
中图分类
关键词
Ezetimibe Hydroxymethylglutaryl-CoA reductase inhibitors Lipids Lipoproteins;

机译：依泽替米贝;羟甲基戊二酰辅酶A还原酶抑制剂;脂质;脂蛋白;

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专利

1. Influence of Previous Statin Therapy on Cholesterol-Lowering Effect of Ezetimibe [J] . Choi Young Hwan, Kim Young, Hyeon Cheol Won, Korean Circulation Journal . 2014,第4期

机译：以前的他汀类药物治疗对依泽替米贝降低胆固醇的影响
2. A comparison of the efficacy of combined ezetimibe and statin therapy with doubling of statin dose in patients with remnant lipoproteinemia on previous statin therapy [J] . NakamuraT., HiranoM., KittaY., Journal of cardiology . 2012,第1a2期

机译：依泽替米贝联合他汀类药物联合他汀类药物剂量加倍治疗残余脂蛋白血症的疗效比较以前的他汀类药物治疗
3. RESEARCH (Recognized effect of Statin and ezetimibe therapy for achieving LDL-C Goal), a randomized, doctor-oriented, multicenter trial to compare the effects of higher-dose statin versus ezetimibe-plus-statin on the serum LDL-C concentration of Japanese [J] . Takeshi Inazawa, Kentaro Sakamoto, Takahide Kohro, Lipids in Health Disease . 2013,第3期

机译：研究（Statin和ezetimibe疗法对实现LDL-C目标的公认作用），一项以医生为中心的随机，多中心试验，比较高剂量他汀类药物与ezetimibe加他汀类药物对日本人血清LDL-C浓度的影响
4. PCSK9 polymorphism rs505151 affects lipid-lowering response to atorvastatin but does not influence ezetimibe therapy in Chilean subjects [C] . Zambrano T, Caama?o JM, Rosales A, International Congress on Coronary Artery Disease . 2011

机译：PCSK9多态性RS505151影响到阿托伐他汀的降脂响应，但不会影响智利受试者的ezetimibe治疗
5. Exploration of a combination Phytosterol and Ezetimibe therapy for the treatment of combined dyslipidemia in a Syrian golden hamster model. [D] . Griffin, John D. 2012

机译：探索植物甾醇和依泽替米贝的组合疗法在叙利亚金仓鼠模型中治疗合并的血脂异常。
6. RESEARCH (Recognized effect of Statin and ezetimibe therapy for achieving LDL-C Goal) a randomized doctor-oriented multicenter trial to compare the effects of higher-dose statin versus ezetimibe-plus-statin on the serum LDL-C concentration of Japanese type-2 diabetes patients design and rationale [O] . Takeshi Inazawa, Kentaro Sakamoto, Takahide Kohro, 2013

机译：研究（Statin和ezetimibe疗法对实现LDL-C目标的公认作用）一项以医生为中心的随机多中心试验比较了大剂量他汀类药物与ezetimibe加他汀类药物对日本人血清LDL-C浓度的影响2型糖尿病患者的设计和基本原理
7. A comparison of the efficacy of combined ezetimibe and statin therapy with doubling of statin dose in patients with remnant lipoproteinemia on previous statin therapy [O] . Nakamura Takamitsu, Hirano Mitsumasa, Kitta Yoshinobu, 2012

机译：依泽替米贝联合他汀类药物加倍他汀类药物治疗残余脂蛋白血症的疗效与以前他汀类药物治疗的比较

Influence of Previous Statin Therapy on Cholesterol-Lowering Effect of Ezetimibe

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