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首页> 美国卫生研究院文献>Neuro-Oncology >P13.26LINEAR ACCELERATOR RADIOSURGERY FOR THE TREATMENT OF NEUROFIBROMATOSIS TYPE 2 RELATED VESTIBULAR SCHWANNOMAS
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P13.26LINEAR ACCELERATOR RADIOSURGERY FOR THE TREATMENT OF NEUROFIBROMATOSIS TYPE 2 RELATED VESTIBULAR SCHWANNOMAS

机译：P13.26线性加速器放射外科手术治疗2型神经纤维瘤相关性前庭神经鞘瘤

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BACKGROUND: Approaches in management of neurofibromatosis type 2 related vestibular schwannomas (VS-NF2) are still controversial. All modern treatment options are less effective in controlling VS-NF2 than sporadic VS. Stereotactic radiosurgery (SRS) can be an alternative to surgery for VS-NF2. We analyzed the efficacy and side effects of SRS in treatment of patients with VS-NF2. MATERIALS AND METHODS: From 2010 till 2013 SRS was applied in twelve patients with 15 VS-NF2. Two patients were previously microsurgical operated with complete and partial removal of VS-NF2. SRS was performed by means of “Trilogy” Linear accelerator (“Varian”, USA) using stereotactic system “Brain Lab” (Germany). Median prescription dose and tumor volume were 12.5Gy (range 12.0-13.0) and 3.564cm3 (range 0.226-8.258), respectively. RESULTS: Twelve patients with 15 VS-NF2 were treated by SRS. Median follow up time was 21 months (from 6 to 35 months). In ten patients follow up was at least 12 months. Tumor growth control was achieved in fourteen (93%) tumors at the moment of the latest MRI. In seven patients after SRS no negative changes in neurological status were seen, in four of them positive changes in neurological status were seen. In three patients with VS-NF2 transitory hearing impairment appeared after SRS. No cases of resistant neuropathic trigeminal pain, considerable facial paresis and occlusive hydrocephalus after SRS were noticed. CONCLUSION: SRS is an effective non-invasive method of treatment of patients with multifocal intracranial lesions associated with NF2 and can be performed as alternative or combined treatment for selected patients.
机译：背景：2型神经纤维瘤病相关的前庭神经鞘瘤（VS-NF2）的管理方法仍存在争议。所有现代治疗方案在控制VS-NF2方面均不如散发VS。立体定向放射外科手术（SRS）可以替代VS-NF2的手术。我们分析了SRS治疗VS-NF2患者的疗效和副作用。材料与方法：从2010年至2013年，SRS被用于12例15 VS-NF2的患者。两名患者此前接受了显微外科手术，部分和部分切除了VS-NF2。 SRS是通过使用立体定向系统“ Brain Lab”（德国）的“ Trilogy”线性加速器（美国“ Varian”）进行的。中位处方剂量和肿瘤体积分别为12.5 Gy（范围12.0-13.0）和3.564cm3（范围0.226-8.258）。结果：12例15 VS-NF2患者接受了SRS治疗。中位随访时间为21个月（6到35个月）。在十名患者中，随访至少12个月。最新的MRI检查表明，在14个（93％）肿瘤中实现了肿瘤生长控制。在SRS后的7例患者中，未观察到神经系统状况的阴性变化，其中4例在神经系统状况中观察到阳性变化。 SRS后出现3例VS-NF2暂时性听力障碍的患者。 SRS后未发现抵抗性神经性三叉神经痛，面部轻瘫和闭塞性脑积水的病例。结论：SRS是治疗与NF2相关的多灶性颅内病变的患者的一种有效的非侵入性方法，可以作为选定患者的替代治疗或联合治疗。

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