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ACTR-84. D-TERMINED: A PHASE 1 TRIAL IN NEWLY DIAGNOSED HIGH GRADE GLIOMA WITH TEMOZOLOMIDE RADIATION AND MINOCYCLINE FOLLOWED BY ADJUVANT MINOCYCLINE/TEMOZOLOMIDE

机译：ACTR-84。 D终止：新诊断的高级别胶质瘤中含有替莫唑胺放射线和次甲基环戊二烯的辅助治疗后的阶段1试验

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BACKGROUNDActivated microglia in high grade gliomas secrete TNF, which activates NF-kappaB. Activation of NF-kB promotes transition to the mesenchymal phenotype of GBM, which is associated with increased radiation-resistance and poorer prognosis. Minocycline is a tetracycline-derivative capable of blocking microglia activation and release of TNF. Minocycline is known to cross the blood-brain barrier and has been shown in vitro and in vivo to inhibit GBM proliferation.

机译：背景高级别神经胶质瘤中的活化小胶质细胞分泌TNF，从而激活NF-κB。 NF-kB的激活促进向GBM的间充质表型的转变，这与抗辐射性增强和预后较差有关。 Minocycline是一种四环素衍生物，能够阻断小胶质细胞的活化和TNF的释放。已知米诺环素会穿过血脑屏障，并已在体外和体内显示出抑制GBM增殖的作用。

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期刊名称 Neuro-Oncology
作者
Adam Cohen; Karthik Sonty; Randy Jensen; Dennis Shrieve; Karen Salzman; Brett Johnson; Melissa Thomas; Whitney Moss; Amanda Behunin; Elizabeth Prystas; Howard Colman;
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年(卷),期 2017(19),Suppl 6
年度 2017
页码 vi19
总页数 1
原文格式 PDF
正文语种
中图分类神经病学;肿瘤学;
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专利

1. Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high-grade gliomas [J] . Schiff David, Desjardins Annick, Cloughesy Timothy, Cancer: A Journal of the American Cancer Society . 2016,第4期

机译：卡博替尼联合替莫唑胺和放疗或放疗后替莫唑胺在新诊断的高级别神经胶质瘤患者中的安全性和药代动力学的1期剂量递增试验
2. Net Clinical Benefit Analysis of Radiation Therapy Oncology Group 0525: A Phase III Trial Comparing Conventional Adjuvant Temozolomide With Dose-Intensive Temozolomide in Patients With Newly Diagnosed Glioblastoma [J] . Terri S. Armstrong, Jeffrey S. Wefel, Meihua Wang, Journal of Clinical Oncology . 2013,第32期

机译：放射治疗肿瘤学0525组的临床净收益分析：Ⅲ期试验，比较新诊断的成胶质细胞瘤患者常规替莫唑胺和剂量密集型替莫唑胺
3. BCNU wafer placement with temozolomide (TMZ) in the immediate postoperative period after tumor resection followed by radiation therapy with TMZ in patients with newly diagnosed high grade glioma: final results of a prospective, multi-institutional, phase II trial [J] . Burri Stuart H., Prabhu Roshan S., Sumrall Ashley L., Journal of neuro-oncology. . 2015,第2期

机译：在新近诊断的高级别神经胶质瘤患者术后，立即在肿瘤切除术后立即使用替莫唑胺（TMZ）放置BCNU晶片，然后进行TMZ放疗：一项前瞻性，多机构，II期试验的最终结果
4. RISK-ADAPTED INTRAVENOUS MELPHALAN WITH ADJUVANT THALIDOMIDE AND DEXAMETHASONE FOR NEWLY DIAGNOSED UNTREATED PATIENTS WITH SYSTEMIC AL AMYLOIDOSIS: INTERIM REPORT OF A PHASE II TRIAL [C] . RL Comenzo, P Zhou, L Reich, International Symposium on Amyloidosis . 2005

机译：风险适应的静脉内莫尔甘蔗用佐剂沙利度胺和地塞米松，用于新诊断的未经治疗的全身淀粉样蛋白症患者：II期试验的中期报告
5. ACTR-28. PHASE 1 DOSE ESCALATION TRIAL OF THE SAFETY OF BMX-001 CONCURRENT WITH RADIATION THERAPY AND TEMOZOLOMIDE IN NEWLY DIAGNOSED PATIENTS WITH HIGH-GRADE GLIOMAS [O] . Katherine Peters, John Kirkpatrick, Ines Batinic-Haberle, -1

机译：ACTR-28。新诊断的高级别胶质瘤患者的BMX-001放射治疗和替莫唑胺治疗安全性的第一阶段剂量递增试验
6. ACTR-84. D-TERMINED: A PHASE 1 TRIAL IN NEWLY DIAGNOSED HIGH GRADE GLIOMA WITH TEMOZOLOMIDE, RADIATION, AND MINOCYCLINE FOLLOWED BY ADJUVANT MINOCYCLINE/TEMOZOLOMIDE [O] . Adam Cohen, Karthik Sonty, Randy Jensen, 2017

机译：ACTR-84。 D-终止：新诊断的高级胶质瘤中的1期试验，用替替唑粒，辐射和米诺环素，然后是佐剂米诺环素/替莫唑啉

ACTR-84. D-TERMINED: A PHASE 1 TRIAL IN NEWLY DIAGNOSED HIGH GRADE GLIOMA WITH TEMOZOLOMIDE RADIATION AND MINOCYCLINE FOLLOWED BY ADJUVANT MINOCYCLINE/TEMOZOLOMIDE

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