首页> 美国卫生研究院文献>Neuro-Oncology >DIPG-73. CLEE011XUS17T (NCT 02607124): A PHASE I/II STUDY OF RIBOCICLIB (LEE011) FOLLOWING RADIATION THERAPY (RT) IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED NON-BIOPSIED DIFFUSE PONTINE GLIOMAS (DIPG) AND RB+ BIOPSIED DIPG AND HIGH GRADE GLIOMAS (HGG)

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DIPG-73. CLEE011XUS17T (NCT 02607124): A PHASE I/II STUDY OF RIBOCICLIB (LEE011) FOLLOWING RADIATION THERAPY (RT) IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED NON-BIOPSIED DIFFUSE PONTINE GLIOMAS (DIPG) AND RB+ BIOPSIED DIPG AND HIGH GRADE GLIOMAS (HGG)

机译：DIPG-73。 CLEE011XUS17T（NCT 02607124）：对新诊断为非双歧性弥漫性人胶质神经胶质糖（DIPG）和RB +双歧杆菌的儿童和年轻成人进行放射治疗（RT）后进行放射治疗（RT）的RIBOCICLIB（LEE011）的I / II期研究）

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INTRODUCTIONDysregulation of the cyclin dependent kinase-retinoblastoma (CDK-RB) pathway is observed in DIPG and HGG. Ribociclib (LEE011) is an oral inhibitor of CDK4/CyclinD1 and CDK6/CyclinD3 complexes that induces RB hypophosphorylation and cell-cycle arrest.

机译：引言在DIPG和HGG中观察到细胞周期蛋白依赖性激酶-视网膜母细胞瘤（CDK-RB）通路的失调。 Ribociclib（LEE011）是CDK4 / CyclinD1和CDK6 / CyclinD3复合物的口服抑制剂，可诱导RB磷酸化不足和细胞周期停滞。

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期刊名称 Neuro-Oncology
作者
Mariko DeWire; Christine Fuller; Trent Hummel; Lionel Chow; Ralph Salloum; Luke Pater; Rachid Drissi; Qing Lu; Charles Stevenson; Adam Lane; John Breneman; David Witte; James Leach; Maryam Fouladi;
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年(卷),期 2018(20),Suppl 2
年度 2018
页码 i64
总页数 1
原文格式 PDF
正文语种
中图分类神经病学;肿瘤学;
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外文文献

1. Phase II Trial of Molecularly Determined Treatment of Children and Young Adults with Newly Diagnosed Diffuse Intrinsic Pontine Gliomas (DIPG): Feasibility and Safety Update [J] . Wright K. D., Bandopadhayay P., Goldman S., Pediatric blood & cancer . 2016,第Suppla3期

机译：儿童和年轻成人新诊断的弥漫性桥本胶质瘤（DIPG）分子确定治疗的II期试验：可行性和安全性更新
2. Nimotuzumab and radiotherapy for treatment of newly diagnosed diffuse intrinsic pontine glioma (DIPG): a phase III clinical study [J] . G. Fleischhack, M. Massimino, M. Warmuth-Metz, Journal of neuro-oncology. . 2019,第1期

机译：Nimotuzumab和放疗用于治疗新诊断的弥漫性内在卵巢胶质瘤（DIPG）：III期临床研究
3. Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG/DIPG working group [J] . Janssens Geert O., Gandola Lorenza, Bolle Stephanie, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2017,第期

机译：弥漫性固有症胶质瘤（DIPG）患者的生存效益在第一次进展中进行再辐射：代表SIOP-E-HGG / DIPG工作组的匹配队列分析
4. DIPG-27. CLEE011XUS17T (NCT 02607124): A PHASE I/II STUDY OF RIBOCICLIB (LEE011) FOLLOWING RADIATION THERAPY IN CHILDREN WITH NEWLY DIAGNOSED NON-BIOPSIED DIFFUSE PONTINE GLIOMAS (DIPG) AND RB+ BIOPSIED DIPG AND HIGH GRADE GLIOMAS (HGG) [O] . Mariko DeWire, Christine Fuller, Trent Hummel, 2017

机译：DIPG-27。 CLEE011XUS17T（NCT 02607124）：在对具有新诊断的非扩散性红斑胶质神经胶质（DIPG）和RB +生物成色的DIPG和高格拉斯胶质蛋白的儿童进行放射治疗后RIBOCICLIB（LEE011）的I / II期研究
5. DIPG-73. CLEE011XUS17T (NCT 02607124): A PHASE I/II STUDY OF RIBOCICLIB (LEE011) FOLLOWING RADIATION THERAPY (RT) IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED NON-BIOPSIED DIFFUSE PONTINE GLIOMAS (DIPG) AND RB+ BIOPSIED DIPG AND HIGH GRADE GLIOMAS (HGG) [O] . Mariko DeWire, Christine Fuller, Trent Hummel, 2018

机译：DIPG-73。 Clee011xus17t（NCT 02607124）：儿童和年轻成人的放射治疗（RT）后核酸核苷酸（LEE011）的一期I / II研究，具有新诊断的非活检弥漫性Pontine Gliomas（DIPG）和RB +活检DIPG和高级GLIMAS（HGG ）

DIPG-73. CLEE011XUS17T (NCT 02607124): A PHASE I/II STUDY OF RIBOCICLIB (LEE011) FOLLOWING RADIATION THERAPY (RT) IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED NON-BIOPSIED DIFFUSE PONTINE GLIOMAS (DIPG) AND RB+ BIOPSIED DIPG AND HIGH GRADE GLIOMAS (HGG)

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