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首页> 美国卫生研究院文献>NPJ Microgravity >Hip load capacity cut-points for Astronaut Skeletal Health NASA Finite Element Strength Task Group Recommendations
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Hip load capacity cut-points for Astronaut Skeletal Health NASA Finite Element Strength Task Group Recommendations

机译：宇航员骨骼健康NASA有限元力量任务组建议的臀部负荷能力临界点

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Concerns raised at a 2010 Bone Summit held for National Aeronautics and Space Administration Johnson Space Center led experts in finite element (FE) modeling for hip fracture prediction to propose including hip load capacity in the standards for astronaut skeletal health. The current standards for bone are based upon areal bone mineral density (aBMD) measurements by dual X-ray absorptiometry (DXA) and an adaptation of aBMD cut-points for fragility fractures. Task Group members recommended (i) a minimum permissible outcome limit (POL) for post-mission hip bone load capacity, (ii) use of FE hip load capacity to further screen applicants to astronaut corps, (iii) a minimum pre-flight standard for a second long-duration mission, and (iv) a method for assessing which post-mission physical activities might increase an astronaut’s risk for fracture after return. QCT-FE models of eight astronaut were analyzed using nonlinear single-limb stance (NLS) and posterolateral fall (NLF) loading configurations. QCT data from the Age Gene/Environment Susceptibility (AGES) Reykjavik cohort and the Rochester Epidemiology Project were analyzed using identical modeling procedures. The 75th percentile of NLS hip load capacity for fractured elderly males of the AGES cohort (9537N) was selected as a post-mission POL. The NLF model, in combination with a Probabilistic Risk Assessment tool, was used to assess the likelihood of exceeding the hip load capacity during post-flight activities. There was no recommendation to replace the current DXA-based standards. However, FE estimation of hip load capacity appeared more meaningful for younger, physically active astronauts and was recommended to supplement aBMD cut-points.
机译：在为美国国家航空航天局（National Aeronautic and Space Administration）举行的2010骨峰会上，约翰逊航天中心（John Space Center）引发的担忧促使髋关节骨折预测的有限元（FE）建模专家提出了将髋部负荷能力纳入宇航员骨骼健康标准的建议。当前的骨标准基于通过双X射线吸收法（DXA）进行的面骨矿物质密度（aBMD）测量以及对脆性骨折的aBMD切入点的调整。工作组成员建议（i）任务后髋骨负荷能力的最低允许结果限值（POL），（ii）利用FE髋骨负荷能力进一步筛选宇航员的申请人，（iii）最低飞行前标准进行第二次长期任务，以及（iv）评估哪些任务后的体育活动可能会增加宇航员返回后骨折的风险。使用非线性单肢姿态（NLS）和后外侧跌落（NLF）加载配置分析了八名宇航员的QCT-FE模型。使用相同的建模程序分析了来自雷克雅未克年龄基因/环境易感性（AGES）队列和罗切斯特流行病学项目的QCT数据。选择年龄在AGES队列中的老年男性（9537N）的NLS髋关节负荷能力的第75个百分位作为任务后POL。 NLF模型与概率风险评估工具相结合，用于评估飞行后活动期间超过髋关节负荷能力的可能性。没有建议取代当前基于DXA的标准。然而，FE估计的髋关节负荷能力对年轻，身体活跃的宇航员而言更有意义，因此建议补充aBMD临界点。

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