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Computer programs in nucleic acid synthesis: synthetic strategy development using solid-phase chemical techniques with data storage retrieval and analysis capabilities.

机译：核酸合成中的计算机程序：使用具有数据存储检索和分析功能的固相化学技术开发合成策略。

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摘要

A computer program has been designed to aid development of synthetic strategies for oligonucleotides produced by solid-phase chemical techniques. The program reduces the time required to develop a strategy and a data file from hours to minutes. The program contains inventories, provides cost analyses, and generates and stores other associated data. The program searches an inventory of sequences for that sequence to avoid duplicate synthesis. If the sequence is not in the inventory the program devises a synthetic strategy, calculates the amounts of reagents and labor costs necessary to complete the synthetic oligonucleotide. The program also deducts the reagents from inventory files. Physical data is also calculated. A file is generated in a sequence inventory for storage of the data as well as other data that will be generated during the purification processes. All variable parameters can be easily edited. The programs were designed to provide a cross-referencing feature for data analysis and can use several parameters as a constant.

机译：已经设计了计算机程序来辅助开发通过固相化学技术产生的寡核苷酸的合成策略。该程序将制定策略和数据文件所需的时间从数小时减少到数分钟。该程序包含库存，提供成本分析以及生成和存储其他关联数据。该程序在序列清单中搜索该序列，以避免重复合成。如果序列不在清单中，则程序会设计一个合成策略，计算完成合成寡核苷酸所需的试剂量和人工成本。该程序还从库存文件中扣除试剂。还计算物理数据。在序列清单中生成一个文件，用于存储数据以及在纯化过程中将生成的其他数据。所有可变参数均可轻松编辑。这些程序旨在为数据分析提供交叉引用功能，并且可以使用多个参数作为常量。

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期刊名称 Nucleic Acids Research
作者
S Lombardi; H Seidell; S Pulford; W Dutton; S Parekh;
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作者单位

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年(卷),期 1984(12),1 Pt 2
年度 1984
页码 437–446
总页数 10
原文格式 PDF
正文语种
中图分类分子生物学;
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专利

1. Computer programs in nucleic acid synthesis: synthetic strategy development using solid-phase chemical techniques with data storage, retrieval and analysis capabilites [J] . Hollis Seidell, Shirish Parekh, Stephen Lombardi, Nucleic acids research . 1984,第1Part2期

机译：核酸合成计算机程序：使用固相化学技术开发合成策略，并具有数据存储，检索和分析功能
2. Computer programs in nucleic acid synthesis: synthetic strategy development using solid-phase chemical techniques with data storage, retrieval and analysis capabilites [J] . Hollis Seidell, Shirish Parekh, Stephen Lombardi, Nucleic acids research . 1984,第1Part2期

机译：核酸合成计算机程序：使用固相化学技术开发合成策略，并具有数据存储，检索和分析功能
3. Computer programs in nucleic acid synthesis: synthetic strategy development using solid-phase chemical techniques with data storage, retrieval and analysis capabilities [J] . Hollis Seidell, Shirish Parekh, Stephen Lombardi, Nucleic acids research . 1984,第5期

机译：核酸合成中的计算机程序：使用具有数据存储，检索和分析功能的固相化学技术开发合成策略
4. Solid-phase synthesis of peptide nucleic acids from N-tetrachlorophthaloyl protected monomers [C] . Xavier F.Mejias Ruiz, Marta Planas, Esther Cros, European Peptide Symposium . 2002

机译：肽核酸的固相合成来自N-四氯邻氯邻氯邻苯甲酰基的单体
5. Chemical studies on the synthesis of nucleic acids and nucleic acid analogues. [D] . Miller, Tod Jeffrey. 1997

机译：核酸和核酸类似物合成的化学研究。
6. Computer programs in nucleic acid synthesis: synthetic strategy development using solid-phase chemical techniques with data storage retrieval and analysis capabilities. [O] . S Lombardi, H Seidell, S Pulford, 1984

机译：核酸合成中的计算机程序：使用具有数据存储检索和分析功能的固相化学技术开发合成策略。
7. Computer programs in nucleic acid synthesis: synthetic strategy development using solid-phase chemical techniques with data storage, retrieval and analysis capabilities. [O] . Lombardi, S, Seidell, H, Pulford, S, 1984

机译：核酸合成中的计算机程序：使用具有数据存储，检索和分析功能的固相化学技术开发合成策略。

Computer programs in nucleic acid synthesis: synthetic strategy development using solid-phase chemical techniques with data storage retrieval and analysis capabilities.

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