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A 22-bipyridine ligand for incorporation into oligodeoxynucleotides: synthesis stability and fluorescence properties of ruthenium-DNA complexes.

机译：用于掺入寡脱氧核苷酸的22-联吡啶配体：钌-DNA复合物的合成稳定性和荧光性质。

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摘要

A non-nucleoside linker based upon the ligand 2,2'-bipyridine and ethylene glycol is prepared and placed into the backbone of a number of oligonucleo-tides. The bipyridine ligand is reacted with cis -dichloro bis(2,2'-bipyridyl) Ru(II) to generate the relatively substitutionally inert complex based upon the well-characterized tris -2,2'-bipyridyl Ru(II). The ruthenium-containing DNA complexes exhibited UV and fluorescence characteristics that are consistent with those previously observed for simple tris -2,2'-bipyridyl Ru(II) complexes. Oligonucleotides containing the ruthenium complex will form both DNA duplexes and triplexes with stabilities that are slightly better than those formed from simple tethered oligonucleotide probes in which the two hybridizing sequences are tethered by simple tri(ethylene glycol) or hexa(ethylene glycol) linkers.

机译：制备了基于配体2，2′-联吡啶和乙二醇的非核苷接头，并将其置于许多寡核苷酸的骨架中。使联吡啶配体与顺-二氯双（2,2'-联吡啶基）Ru（II）反应，生成基于特征充分的三-2,2'-联吡啶基Ru（II）的相对取代的惰性络合物。含钌的DNA配合物表现出的紫外线和荧光特征与以前对简单的tris -2,2'-联吡啶基Ru（II）配合物观察到的一致。含有钌复合物的寡核苷酸将形成DNA双链体和三链体，其稳定性比由简单的拴系寡核苷酸探针形成的DNA稳定性好，在简单的拴系寡核苷酸探针中，两个杂交序列通过简单的三（乙二醇）或六（乙二醇）接头拴系。

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期刊名称 Nucleic Acids Research
作者
K Wiederholt; L W McLaughlin;
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作者单位

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年(卷),期 1999(27),12
年度 1999
页码 2487–2493
总页数 7
原文格式 PDF
正文语种
中图分类分子生物学;
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专利

1. A 2,2"-bipyridine ligand for incorporation into oligodeoxynucleotides: synthesis, stability and fluorescence properties of ruthenium-DNA complexes. [J] . Wiederholt K, McLaughlin LW Nucleic Acids Research . 1999,第12期

机译：用于掺入寡脱氧核苷酸的2,2“-联吡啶配体：钌-DNA复合物的合成，稳定性和荧光性质。
2. A 2,2′-bipyridine ligand for incorporation into oligodeoxynucleotides: Synthesis, stability and fluorescence properties of ruthenium—DNA complexes [J] . Kristin Wiederholt, Larry W. McLaughlin Nucleic acids research . 1999,第12期

机译：用于掺入寡脱氧核苷酸的2,2'-联吡啶配体：钌-DNA复合物的合成，稳定性和荧光性质
3. Improving the moisture stability of a 3D zinc-organic framework by incorporating methyl groups into the auxiliary ligand: Synthesis, characterization, luminescence and catalytic properties [J] . Ma De-Yun, Li Xiang, Wu Xian-Ge, Journal of Molecular Structure . 2015,第Null期

机译：通过将甲基结合到辅助配体中来改善3D锌有机骨架的水分稳定性：合成，表征，发光和催化性能
4. Synthesis and characterization of chromone-based ligand and its fluorescence property towards Zn~(2+) [C] . W M H Arifin, Y Juahir, N N M Ali International Fundamentum Science Symposium . 2019

机译：施氮铬酮基配体的合成与表征〜Zn〜（2+）的荧光性能
5. Synthesis, Structural and Electronic Properties, and Reactivity of Group 5 Metal Complexes Incorporating the Redox-Active [ONO] Ligand Platform. [D] . Hananouchi, Steven Paul. 2014

机译：结合了氧化还原活性[ONO]配体平台的5族金属配合物的合成，结构和电子性能以及反应性。
6. Synthesis and Characterization of Acyclic and Cyclic Aza-bridged Ligands Incorporating 22-Bipyridine Subunits and Their Complexes With Copper(II) Cobalt(II) and Nickel(II) [O] . Antonino Mamo, Andrea Pappalardo 2003

机译：含22-联吡啶亚基及其与铜（II）钴（II）和镍（II）的配合物的无环环状氮杂桥联配体的合成与表征
7. A 2,2"-bipyridine ligand for incorporation into oligodeoxynucleotides: synthesis, stability and fluorescence properties of ruthenium-DNA complexes. [O] . Wiederholt, K, McLaughlin, L W 1999

机译：用于掺入寡脱氧核苷酸的2,2“-联吡啶配体：钌-DNA复合物的合成，稳定性和荧光性质。
8. Oxidation State Properties of Delocalized, Ligand-Bridged Metal Complexes. (Ru3O(CH3CO2)6L3)n+ and the Pyrazine-Bridged, Cluster-Cluster Dimer, (Ru3O(CH3CO2)6(py)2)2pyzm+. [R] . Wilson, S. T., Bondurant, R. F., Meyer, T. J., 1975

机译：离域，配体桥联金属配合物的氧化态特性。（Ru 3 O（CH 3 CO 2）6 L 3）n +和吡嗪桥联，簇 - 簇二聚体，（Ru 3 O（CH 3 CO 2）6（py）2）2pyzm +。

A 22-bipyridine ligand for incorporation into oligodeoxynucleotides: synthesis stability and fluorescence properties of ruthenium-DNA complexes.

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