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Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database: an expanded data model integrating natural language text and sequence analysis programs

机译:人类免疫缺陷病毒 逆转录和蛋白酶序列数据库:扩展 结合自然语言文本和序列分析的数据模型 程式

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摘要

The HIV Reverse Transcriptase and Protease Sequence Database is an on-line relational database that catalogs evolutionary and drug-related sequence variation in the human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease enzymes, the molecular targets of anti-HIV therapy (). The database contains a compilation of nearly all published HIV RT and protease sequences, including submissions from International Collaboration databases and sequences published in journal articles. Sequences are linked to data about the source of the sequence sample and the antiretroviral drug treatment history of the individual from whom the isolate was obtained. During the past year 3500 sequences have been added and the data model has been expanded to include drug susceptibility data on sequenced isolates. Database content has also been integrated with didactic text and the output of two sequence analysis programs>.
机译:HIV逆转录酶和蛋白酶序列数据库是一个在线关系数据库,该数据库对人类免疫缺陷病毒(HIV)逆转录酶(RT)和蛋白酶(这是抗HIV治疗的分子靶标, )。该数据库包含几乎所有已发布的HIV RT和蛋白酶序列的汇编,包括来自国际合作数据库的投稿以及发表在期刊文章上的序列。序列链接到有关序列样品来源和获得分离株的个体的抗逆转录病毒药物治疗史的数据。在过去的一年中,增加了3500个序列,数据模型得到扩展,以包括测序分离物的药物敏感性数据。数据库内容也已与教学文本和两个序列分析程序的输出集成在一起。>。

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