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首页> 美国卫生研究院文献>Nutrients >Prostatic Response to Supranutritional Selenium Supplementation: Comparison of the Target Tissue Potency of Selenomethionine vs. Selenium-Yeast on Markers of Prostatic Homeostasis
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Prostatic Response to Supranutritional Selenium Supplementation: Comparison of the Target Tissue Potency of Selenomethionine vs. Selenium-Yeast on Markers of Prostatic Homeostasis

机译：补充营养超标的前列腺反应：硒蛋氨酸与硒酵母的目标组织效能在前列腺稳态中的比较

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Prostate cancer is the product of dysregulated homeostasis within the aging prostate. Supplementation with selenium in the form of selenized yeast (Se-yeast) significantly reduced prostate cancer incidence in the Nutritional Prevention of Cancer Trial. Conversely, the Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed no such cancer-protective advantage using selenomethionine (SeMet). The possibility that SeMet and Se-yeast are not equipotent in promoting homeostasis and cancer risk reduction in the aging prostate has not been adequately investigated; no direct comparison has ever been reported in man or animals. Here, we analyzed data on prostatic responses to SeMet or Se-yeast from a controlled feeding trial of 49 elderly beagle dogs—the only non-human species to frequently develop prostate cancer during aging—randomized to one of five groups: control; low-dose SeMet, low-dose Se-yeast (3 μg/kg); high-dose SeMet, high-dose Se-yeast (6 μg/kg). After seven months of supplementation, we found no significant selenium form-dependent differences in toenail or intraprostatic selenium concentration. Next, we determined whether SeMet or Se-yeast acts with different potency on six markers of prostatic homeostasis that likely contribute to prostate cancer risk reduction—intraprostatic dihydrotestosterone (DHT), testosterone (T), DHT:T, and epithelial cell DNA damage, proliferation, and apoptosis. By analyzing dogs supplemented with SeMet or Se-yeast that achieved equivalent intraprostatic selenium concentration after supplementation, we showed no significant differences in potency of either selenium form on any of the six parameters over three different ranges of target tissue selenium concentration. Our findings, which represent the first direct comparison of SeMet and Se-yeast on a suite of readouts in the aging prostate that reflect flux through multiple gene networks, do not further support the notion that the null results of SELECT are attributable to differences in prostatic consequences achievable through daily supplementation with SeMet, rather than Se-yeast.
机译：前列腺癌是前列腺衰老过程中体内稳态失调的产物。在癌症营养预防试验中，添加硒化硒酵母（硒酵母）形式的硒可显着降低前列腺癌的发病率。相反，使用硒代蛋氨酸（SeMet）进行的硒和维生素E癌症预防试验（SELECT）没有显示出这种癌症保护优势。 SeMet和Se-yeast在促进体内稳态和降低衰老前列腺癌的癌症风险方面不均等的可能性尚未得到充分研究；没有关于人类或动物的直接比较的报道。在这里，我们分析了49只老年比格犬（唯一在衰老过程中经常发展成前列腺癌的非人类物种）的对照喂养试验对SeMet或Se-酵母的前列腺反应的数据，随机分为五组之一：低剂量SeMet，低剂量Se-酵母（3μg/ kg）;大剂量SeMet，大剂量Se-酵母（6μg/ kg）。补充七个月后，我们发现趾甲或前列腺内硒浓度没有明显的硒形式依赖性差异。接下来，我们确定SeMet或Se-yeast对可能有助于降低前列腺癌风险的六个前列腺稳态稳态标志物-前列腺内双氢睾丸激素（DHT），睾丸激素（T），DHT：T和上皮细胞DNA损伤的作用不同，增殖和凋亡。通过分析补充了SeMet或Se-yeast的狗，它们在补充后达到了相同的前列腺内硒浓度，我们发现在三种目标组织硒浓度范围内的六个参数中，任何一个硒形式的效力均无显着差异。我们的发现代表了SeMet和Se-yeast在衰老的前列腺中的一系列读数上的首次直接比较，这些读数反映了通过多个基因网络的通量，但并不进一步支持SELECT无效结果归因于前列腺差异的观点。通过每天补充SeMet而不是Se-yeast可获得的后果。

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