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首页> 美国卫生研究院文献>Nutrients >Anti-Inflammatory Activity of Fruit Fractions in Vitro Mediated through Toll-Like Receptor 4 and 2 in the Context of Inflammatory Bowel Disease
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Anti-Inflammatory Activity of Fruit Fractions in Vitro Mediated through Toll-Like Receptor 4 and 2 in the Context of Inflammatory Bowel Disease

机译：在炎性肠病的背景下通过类似收费的受体4和2介导的水果部分的体外抗炎活性

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摘要

Pattern recognition receptors such as Toll-Like Receptor 2 (TLR2) and 4 (TLR4) are important in detecting and responding to stress and bacterial stimuli. Defect or damage in the TLR2 and TLR4 pathways can lead to sustained inflammation, characteristic of inflammatory bowel disease (IBD). The goal of this study was to identify fruit fractions that can be tested further to develop them as complementary therapies for IBD. In order to do this, we identified fruit fractions that mediate their anti-inflammatory response through the TLR4 and TLR2 pathway. Human Embryonic Kidney (HEK)-hTLR4 and hTLR2 cells were stimulated with their respective ligands to induce inflammation. These cells were treated with one of the 12 fractionated fruits and the inflammatory effect measured. 10 of the fruits came up as anti-inflammatory in the hTLR4 assay and nine in the hTLR2 assays. Many of the fruit fractions mediated their anti-inflammatory actions either mainly in their hydrophobic fractions (such as elderberry) or hydrophilic fractions (such as red raspberry), or both. The strongest anti-inflammatory effects were seen for feijoa and blackberry. This study shows that fruits can have multiple fractions eliciting anti-inflammatory effects in a pathway specific manner. This suggests that the compounds found in fruits can act together to produce health benefits by way of reducing inflammation. Exploiting this property of fruits can help develop complimentary therapies for inflammatory diseases.
机译：模式识别受体，例如Toll-Like受体2（TLR2）和4（TLR4），对于检测压力和对细菌和刺激的反应非常重要。 TLR2和TLR4途径的缺陷或破坏可导致持续性炎症，这是炎症性肠病（IBD）的特征。这项研究的目的是确定可进一步测试以将其开发为IBD补充疗法的水果级分。为此，我们确定了通过TLR4和TLR2途径介导其抗炎反应的水果级分。用其各自的配体刺激人胚肾（HEK）-hTLR4和hTLR2细胞以诱导炎症。这些细胞用12种分级水果之一处理，并测量了炎症反应。在hTLR4分析中有10种水果具有抗炎作用，在hTLR2分析中有9种水果具有抗炎作用。许多水果级分主要通过其疏水级分（例如接骨木浆果）或亲水级分（例如红树莓）或两者，介导其抗炎作用。对美jo和黑莓的抗炎作用最强。这项研究表明，水果可以具有多种途径以途径特异性方式引发抗炎作用。这表明水果中发现的化合物可以共同发挥作用，通过减少炎症来产生健康益处。利用水果的这种特性可以帮助开发针对炎症性疾病的补充疗法。

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