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首页> 美国卫生研究院文献>Nutrients >The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients in Canada
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The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients in Canada

机译：加拿大一组克罗恩病患者的维生素D状况与疾病活动的关系

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We determined the association between vitamin D status as 25hydroxyvitamin D [25(OH)D] and disease activity in a cohort of 201 Crohn’s Disease (CD) patients in Saskatoon, Canada over three years. The association between high-sensitivity C-reactive protein (hs-CRP) and 25(OH)D and several disease predictors were evaluated by the generalized estimating equation (GEE) over three time-point measurements. A GEE binary logistic regression test was used to evaluate the association between vitamin D status and the Harvey-Bradshaw Index (HBI). The deficient vitamin D group (≤29 nmol/L) had significantly higher mean hs-CRP levels compared with the three other categories of vitamin D status (p < 0.05). CRP was significantly lower in all of the other groups compared with the vitamin D-deficient group, which had Coef. = 12.8 units lower (95% CI −19.8, −5.8), Coef. 7.85 units (95% CI −14.9, −0.7), Coef. 9.87 units (95% CI −17.6, −2.0) for the vitamin D insufficient, adequate, and optimal groups, respectively. The vitamin D status was associated with the HBI active disease category. However, the difference in the odds ratio compared with the reference category of deficient vitamin D category was only significant in the insufficient category (odds ratio = 3.45, p = 0.03, 95% CI 1.0, 10.8). Vitamin D status was inversely associated with indicators of disease activity in Crohn’s disease, particularly with the objective measures of inflammation.
机译：我们确定了加拿大萨斯卡通的201名克罗恩病（CD）患者在三年内的25种维生素D状态（25羟基维生素D [25（OH）D]）与疾病活动之间的关系。在三个时间点测量中，通过广义估计方程（GEE）评估了高敏C反应蛋白（hs-CRP）和25（OH）D与几种疾病预测因子之间的关联。 GEE二元逻辑回归测试用于评估维生素D状态与Harvey-Bradshaw指数（HBI）之间的关联。与其他三类维生素D状态相比，缺乏维生素D组（≤29nmol / L）的hs-CRP平均水平显着更高（p <0.05）。与缺乏Coef的维生素D缺乏组相比，所有其他组的CRP均显着降低。 =低12.8个单位（95％CI -19.8，-5.8），Coef。 7.85单位（95％CI -14.9，-0.7），Coef。维生素D不足，充足和最佳组分别为9.87单位（95％CI -17.6，-2.0）。维生素D的状态与HBI活动性疾病类别有关。但是，与维生素D缺乏类别的参考类别相比，优势比的差异仅在维生素D不足类别中才有意义（优势比= 3.45，p = 0.03，95％CI 1.0，10.8）。维生素D的状态与克罗恩病的疾病活动性指标成反比，特别是与炎症的客观指标有关。

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