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Diet Hypotheses in Light of the Microbiota Revolution: New Perspectives

机译:微生物菌群革命的饮食假说:新观点

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摘要

From an evolutionary standpoint, allergy has only recently emerged as a significant health problem. Various hypotheses were proposed to explain this, but they all indicated the importance of rapid lifestyle changes, which occurred in industrialized countries in the last few decades. In this review, we discuss evidence from epidemiological and experimental studies that indicate changes in dietary habits may have played an important role in this phenomenon. Based on the example of dietary fiber, we discuss molecular mechanisms behind this and point towards the importance of diet-induced changes in the microbiota. Finally, we reason that future studies unraveling mechanisms governing these changes, along with the development of better tools to manipulate microbiota composition in individuals will be crucial for the design of novel strategies to combat numerous inflammatory disorders, including atopic diseases.
机译:从进化的角度来看,变态反应直到最近才成为一个重大的健康问题。提出了各种假设来解释这一点,但是它们都表明了快速改变生活方式的重要性,这种改变发生在过去几十年的工业化国家中。在这篇综述中,我们讨论了流行病学和实验研究的证据,这些证据表明饮食习惯的改变可能在这一现象中起了重要作用。以膳食纤维为例,我们讨论了其背后的分子机制,并指出了饮食引起的微生物群变化的重要性。最后,我们认为,未来的研究将揭示控制这些变化的机制,以及开发更好的工具来控制个体中的微生物群,对于设计新的策略来对抗多种炎性疾病(包括特应性疾病)至关重要。

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