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首页> 美国卫生研究院文献>Nutrients >Effects of Chronic Vitamin D3 Hormone Administration on Anxiety-Like Behavior in Adult Female Rats after Long-Term Ovariectomy
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Effects of Chronic Vitamin D3 Hormone Administration on Anxiety-Like Behavior in Adult Female Rats after Long-Term Ovariectomy

机译：长期服用维生素D3激素对成年雌性大鼠长期卵巢切除术后焦虑行为的影响

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The present preclinical study was created to determine the therapeutic effects of vitamin D hormone treatment as an adjunctive therapy alone or in a combination with low dose of 17β-estradiol (17β-E2) on anxiety-like behavior in female rats with long-term absence of estrogen. Accordingly, the aim of the current study was to examine the effects of chronic cholecalciferol administration (1.0, 2.5 or 5.0 mg/kg subcutaneously, SC, once daily, for 14 days) on the anxiety-like state after long-term ovariectomy in female rats. Twelve weeks postovariectomy, cholecalciferol was administered to ovariectomized (OVX) rats and OVX rats treated with 17β-E2 (0.5 µg/rat SC, once daily, for 14 days). Anxiety-like behavior was assessed in the elevated plus maze (EPM) and the light/dark test (LDT), and locomotor and grooming activities were tested in the open field test (OFT). Cholecalciferol at two doses of 1.0 and 2.5 mg/kg alone or in combination with 17β-E2 produced anxiolytic-like effects in OVX rats as evidenced in the EPM and the LDT, as well as increased grooming activity in the OFT. Our results indicate that cholecalciferol, at two doses of 1.0 and 2.5 mg/kg, has a profound anxiolytic-like effects in the experimental rat model of long-term estrogen deficiency.
机译：创建本临床前研究的目的在于确定维生素D激素单独治疗或与低剂量17β-雌二醇（17β-E2）联合使用对长期缺乏的雌性大鼠焦虑样行为的治疗效果雌激素因此，本研究的目的是检查长期胆囊切除术后长期服用胆钙化固醇（皮下注射1.0、2.5或5.0 mg / kg，SC，每天一次，连续14天）对焦虑样状态的影响。大鼠。卵巢切除术后十二周，将胆钙化固醇用于卵巢切除的（OVX）大鼠和用17β-E2（0.5 µg /大鼠SC，每天一次，连续14天）治疗的OVX大鼠。在高架迷宫（EPM）和明/暗测试（LDT）中评估了类似焦虑的行为，并在野外测试（OFT）中测试了运动和修饰活动。 EPM和LDT证明，单独使用1.0和2.5 mg / kg两种剂量或与17β-E2组合使用的胆钙化固醇在OVX大鼠中产生抗焦虑样作用，并在OFT中增强修饰活性。我们的结果表明，胆钙化固醇在1.0和2.5 mg / kg的两种剂量下，在长期雌激素缺乏的实验大鼠模型中具有深远的抗焦虑作用。

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