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首页> 美国卫生研究院文献>Nutrients >Non-Alcoholic Fatty Liver Disease Is Associated with Higher Metabolic Expenditure in Overweight and Obese Subjects: A Case-Control Study
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Non-Alcoholic Fatty Liver Disease Is Associated with Higher Metabolic Expenditure in Overweight and Obese Subjects: A Case-Control Study

机译：非酒精性脂肪性肝病与超重和肥胖受试者代谢代谢费用增加相关：病例对照研究

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Non-alcoholic fatty liver disease (NAFLD) is a common condition in Western countries. However, their metabolic characteristics are poorly known even though they could be important. Therefore, the objective of this study was to measure resting metabolic parameters in overweight/obese adults with hepatic steatosis compared to controls, matched for age, sex, and obesity level. Hepatic steatosis was diagnosed with liver ultrasound. Energy metabolism was measured with indirect calorimetry: energy expenditure (REE), predicted REE, the ratio between REE and the predicted REE, and the respiratory quotient (RQ) were reported. We measured some anthropometric, body composition, and bio-humoral parameters; 301 participants with NAFLD were matched for age, sex, and obesity level with 301 participants without NAFLD. People with NAFLD showed significantly higher REE (1523 ± 238 vs. 1464 ± 212 kcal, p = 0.005), REE/REE predicted ratio (98.2 ± 9.4 vs. 95.7 ± 8.1, p = 0.002), and RQ (0.88 ± 0.08 vs. 0.85 ± 0.07, p = 0.03). Moreover, the NAFLD group had significantly higher inflammatory and insulin-resistance parameters compared to controls. In conclusion, NAFLD is associated with a significantly higher metabolic expenditure, as measured with indirect calorimetry, compared to a similar cohort of individuals without this condition. Higher inflammatory levels in patients with NAFLD can probably explain our findings, even if other research is needed on this issue.
机译：非酒精性脂肪肝疾病（NAFLD）在西方国家很普遍。然而，尽管它们的代谢特征可能很重要，但鲜为人知。因此，本研究的目的是测量与对照组相比年龄，性别和肥胖水平相匹配的超重/肥胖肝脂肪变性成年人的静息代谢参数。肝超声诊断为肝脂肪变性。用间接量热法测量能量代谢：报告了能量消耗（REE），预测REE，REE与预测REE之间的比率以及呼吸商（RQ）。我们测量了一些人体测量学，身体组成和生物体液参数； 301名有NAFLD的参与者的年龄，性别和肥胖水平与301名无NAFLD的参与者相匹配。患有NAFLD的人显示出明显更高的REE（1523±238 vs.1464±212 kcal，p = 0.005），REE / REE预测比率（98.2±9.4 vs. 95.7±8.1，p = 0.002）和RQ（0.88±0.08 vs 0.85±0.07，p = 0.03）。此外，与对照组相比，NAFLD组的炎症和胰岛素抵抗参数明显更高。总之，与没有这种情况的相似人群相比，用间接量热法测量，NAFLD与明显更高的代谢消耗有关。即使需要就此问题进行其他研究，NAFLD患者中较高的炎症水平也可能可以解释我们的发现。

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