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A Safety and Survival Analysis of Neoadjuvant Bevacizumab with Standard Chemoradiation in a Phase I/II Study Compared with Standard Chemoradiation in Locally Advanced Rectal Cancer

机译：在局部晚期直肠癌中I / II期与标准化学放疗相比标准化学放疗的新辅助贝伐单抗的安全性和生存分析

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Introduction.Bevacizumab is increasingly being tested with neoadjuvant regimens in patients with localized cancer, but its effects on metastasis and survival remain unknown. This study examines the long-term outcome of clinical stage II/III rectal cancer patients treated in a prospective phase II study of bevacizumab with chemoradiation and surgery. As a benchmark, we used data from an analysis of 42 patients with locally advanced rectal cancer treated with a contemporary approach of preoperative fluoropyrimidine-based radiation therapy.

机译：简介：贝伐单抗越来越多地在局部癌症患者中接受新辅助方案的测试，但其对转移和生存的影响尚不清楚。这项研究检查了贝伐珠单抗通过化学放疗和手术进行的前瞻性II期研究中治疗的临床II / III期直肠癌患者的长期结局。作为基准，我们使用对42例采用现代术前氟嘧啶放射治疗方法治疗的局部晚期直肠癌患者的分析数据。

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期刊名称 The Oncologist
作者
Christopher G. Willett; Dan G. Duda; Marek Ancukiewicz; Mira Shah; Brian G. Czito; Rex Bentley; Martin Poleski; Hiroshi Fujita; Gregory Y. Lauwers; Madeline Carroll; Douglas Tyler; Christopher Mantyh; Paul Shellito; Daniel C. Chung; Jeffrey W. Clark; Rakesh K. Jain;
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作者单位

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年(卷),期 2010(15),8
年度 2010
页码 845–851
总页数 7
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Bevacizumab Neoadjuvant Rectal cancer Chemoradiation Toxicity;

机译：贝伐单抗;新辅助药;直肠癌;化学放射;毒性;

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专利

1. 奥沙利铂和卡培他滨联合贝伐单抗加放疗的新辅助方案治疗局部晚期直肠癌:单中心Ⅱ期研究结果 [J] . Xin Yu, De-sen Wan, Pei-rong Ding, 癌症（英文版） . 2018,第008期
2. A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer. [J] . Willett CG, Duda DG, Ancukiewicz M, The oncologist . 2010,第8期

机译：在局部晚期直肠癌中，与标准化学放疗相比，I / II期研究中标准化学放疗的新辅助贝伐单抗的安全性和生存分析。
3. A Safety and Survival Analysis of Neoadjuvant Bevacizumab with Standard Chemoradiation in a Phase I/II Study Compared with Standard Chemoradiation in Locally Advanced Rectal Cancer [J] . Brian G. Czito, Christopher G. Willett, Christopher Mantyh, The oncologist . 2010,第8期

机译：在局部晚期直肠癌中，I / II期与标准化学放疗相比，标准化学放疗的新辅助贝伐单抗的安全性和生存分析
4. Neoadjuvant Chemotherapy with Capecitabine, Oxaliplatin and Bevacizumab Followed by Concomitant Chemoradiation and Surgical Resection in Locally Advanced Rectal Cancer with High Risk of Recurrence - A Phase II Study [J] . Eisterer Wolfgang, Piringer Gudrun, De Vries Alexander, Anticancer Research: International Journal of Cancer Research and Treatment . 2017,第5期

机译：Neoadjuvant化疗用Capecitabine，Oxaliplatin和Bevacizumab，随后在局部晚期直肠癌中伴随着伴随的直肠癌，具有高的复发风险 - II期研究
5. Texture kinetic features from pre-treatment DCE MRI for predicting pathologic tumor stage regression after neoadjuvant chemoradiation in rectal cancers [C] . Siddhartha Nanda, Jacob T. Antunes, Kaustav Bera, Conference on Medical Imaging: Image-Guided Procedures, Robotic Interventions, and Modeling . 2020

机译：预处理DCE MRI的纹理动力学特征可预测直肠癌新辅助化学放疗后病理性肿瘤分期
6. Intenzivnej?e neoadjuvantno zdravljenje lokalno napredovalnega raka danke =Intensified neoadjuvant treatment of locally advanced rectal cancer [D] . Golo, Danijela. 2018

机译：强烈的Neoadjuvant治疗局部晚期癌症射线=加强Neoadjuvant治疗局部晚期直肠癌
7. Neoadjuvant volumetric modulated arc radiochemotherapy with a simultaneous integrated boost technique compared to standard chemoradiation for locally advanced rectal cancer [O] . Natalia JANKARASHVILI, Sophio KAKHADZE, Maia TOPESHASHVILI, 2019

机译：与标准化学放疗相比新辅助容积调制弧线放射化学疗法与同时化学疗法联合治疗局部晚期直肠癌
8. A Safety and Survival Analysis of Neoadjuvant Bevacizumab with Standard Chemoradiation in a Phase I/II Study Compared with Standard Chemoradiation in Locally Advanced Rectal Cancer [O] . Willett, Christopher G., Duda, Dan G., Ancukiewicz, Marek, 2010

机译：在局部I / II期研究中，标准放化疗与标准放化疗相比，新放疗的贝伐单抗在局部晚期直肠癌中的安全性和生存分析

A Safety and Survival Analysis of Neoadjuvant Bevacizumab with Standard Chemoradiation in a Phase I/II Study Compared with Standard Chemoradiation in Locally Advanced Rectal Cancer

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