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首页> 美国卫生研究院文献>Oncotarget >Trends in the prevalence of congenital hydrocephalus in 14 cities in Liaoning province China from 2006 to 2015 in a population-based birth defect registry from the Liaoning Women and Children’s Health Hospital
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Trends in the prevalence of congenital hydrocephalus in 14 cities in Liaoning province China from 2006 to 2015 in a population-based birth defect registry from the Liaoning Women and Children’s Health Hospital

机译：2006年至2015年辽宁省妇幼保健院以人口为基础的出生缺陷登记册中中国辽宁省14个城市的先天性脑积水流行趋势

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The aim of this study was to assess the prevalence and trends of congenital hydrocephalus (CH) using a large population-based sample with cases retrieved from the Liaoning Birth Defects Registry, which included 14 cities, over a 10-year period. CH prevalence, percent change, average change, and contribution rates of each city were calculated. Statistical analysis was performed using a Poisson regression model. There was a total of 3008 CH cases among 3,248,954 live births during the observational period (9.26 cases/10,000 live births). On average, the prevalence of CH had significantly decreased by 11.84% each year (P < 0.01). The three leading cities with the highest prevalence of CH were Chaoyang (13.73/10,000), Huludao (13.18/10,000), and Fuxin (12.71/10,000), while Yingkou (6.06/10,000), Dalian (6.27/10,000), and Anshan (6.56/10,000) had the lowest prevalence. Notably, significantly decreasing trends were observed in 10 (71.4%) of these 14 cities. In addition, the cities of Fushun, Shenyang, and Dalian had contributed to more than one-third of the decreasing trend in Liaoning province. In conclusion, this study provides evidence of the decreasing prevalence of CH over a 10-year period (2006–2015) in Liaoning province. Preventative efforts should be strengthened to further reduce the risk of CH in these high prevalence areas.
机译：这项研究的目的是使用一个以人口为基础的大型样本，并从包括14个城市在内的辽宁省出生缺陷登记处检索的病例，在10年期间评估先天性脑积水（CH）的患病率和趋势。计算每个城市的CH患病率，变化百分比，平均变化和贡献率。使用泊松回归模型进行统计分析。在观察期内，在3,248,954例活产中共有3008例CH病例（9.26例/ 10,000例活产）。平均而言，CH的患病率每年显着下降11.84％（P <0.01）。 CH患病率最高的三个领先城市是朝阳（13.73 / 10,000），葫芦岛（13.18 / 10,000）和阜新（12.71 / 10,000），营口（6.06 / 10,000），大连（6.27 / 10,000）和鞍山（6.56 / 10,000）的患病率最低。值得注意的是，在这14个城市中有10个（71.4％）观察到显着下降的趋势。此外，抚顺市，沉阳市和大连市占了辽宁省下降趋势的三分之一以上。总之，这项研究提供了证据，证明辽宁省在十年（2006-2015年）内CH的流行率正在下降。应加强预防措施，以进一步减少这些高发地区的CH风险。

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