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Metformin and berberine two versatile drugs in treatment of common metabolic diseases

机译：二甲双胍和小ber碱两种用于治疗常见代谢疾病的通用药物

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Metformin has been used as a glucose lowering drug for several centuries and is now a first-line drug for type 2 diabetes mellitus (T2DM). Since the discovery that it activates AMP-activated protein kinase (AMPK) and reduces risk of cancer, metformin has drawn great attentions. Another drug, berberine, extracted from berberis vulgaris L. (root), was an ancient herbal medicine in treating diarrhea. Ongoing experimental and clinical studies have illuminated great potential of berberine in regulation of glucose and lipid homeostasis, cancer growth and inflammation. Furthermore, the lipid lowering effect of berberine is comparable to those conventional lipid drugs but with low toxicity. Therefore, it is right time to transform beneficial effects of berberine into therapeutic practice. Metformin and berberine share many features in actions despite different structure and both could be excellent drugs in treating T2DM, obesity, cardiac diseases, tumour, as well as inflammation. Since these disorders are often connected and comprise common pathogenic factors that could be targeted by the two drugs, understanding their actions can give us rationale for expansion of their clinical uses.
机译：二甲双胍已被用作降低葡萄糖的药物已有好几个世纪了，现已成为2型糖尿病（T2DM）的一线药物。自从发现它激活AMP激活的蛋白激酶（AMPK）并降低了患癌风险以来，二甲双胍引起了极大的关注。从小小root（根）提取的另一种药品小ber碱是治疗腹泻的古老草药。正在进行的实验和临床研究显示了小ber碱在调节葡萄糖和脂质体内稳态，癌症生长和炎症方面的巨大潜力。此外，小ber碱的降脂作用与传统脂类药物相当，但毒性低。因此，现在是将小ber碱的有益作用转化为治疗实践的恰当时机。尽管结构不同，但二甲双胍和小ber碱在动作上有许多共同之处，并且两者都是治疗T2DM，肥胖，心脏病，肿瘤以及炎症的极好药物。由于这些疾病通常是相互联系的，并且包含两种药物可能针对的常见致病因素，因此了解它们的作用可以为我们扩大其临床用途提供理论依据。

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